Reduced incidence of gastroduodenal ulcers with celecoxib, a novel cyclooxygenase-2 inhibitor, compared to naproxen in patients with arthritis

The American Journal of Gastroenterology
Jay L GoldsteinG S Geis

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) block prostaglandin production by inhibiting cyclooxygenase (COX); they are believed to cause gastroduodenal damage by inhibiting the COX-1 isoform and to have analgesic and anti-inflammatory effects by inhibiting the COX-2 isoform. As compared to conventional NSAIDs, celecoxib, a COX-2 specific inhibitor, has been shown in previous single posttreatment endoscopy studies to be associated with lower gastroduodenal ulcer rates. In response to concerns that such studies may under-represent ulceration rates, the present serial endoscopy study was designed to compare cumulative gastroduodenal ulcer rates associated with the use of celecoxib to those of naproxen, a conventional NSAID. In this double-blind, parallel-group, multicenter study, 537 patients with osteoarthritis (OA) or rheumatoid arthritis (RA) were randomized to treatment with celecoxib 200 mg b.i.d. (n = 270) or naproxen 500 mg b.i.d. (n = 267) for 12 wk. Gastroduodenal damage was determined from esophagogastroduodenoscopy after 4, 8, and 12 wk of therapy. Arthritis efficacy was evaluated with Patient's and Physician's Global Assessments. Gastroduodenal ulcer rates after celecoxib and naproxen treatment were 4% versus 19% in...Continue Reading

References

Feb 1, 1978·The Journal of Clinical Investigation·J W BurchP W Majerus
May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J L MasferrerP Needleman
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·W L XieD L Simmons
May 17, 1991·The American Journal of Medicine·M C Houston
Oct 1, 1990·The Journal of Clinical Investigation·J L MasferrerP Needleman
Mar 1, 1989·Digestive Diseases and Sciences·M G RobinsonC W Warner
Jun 1, 1985·The American Journal of Medicine·J Carmichael, S W Shankel
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D L DeWitt, W L Smith
Dec 1, 1987·Archives of Internal Medicine·S H Roth, R E Bennett
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·K SeibertP Isakson
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·J L MasferrerK Seibert
Sep 1, 1993·Kidney International·D Schlondorff
Aug 9, 1993·The American Journal of Medicine·D L DeWittW L Smith
May 8, 1998·The American Journal of Medicine·M R Griffin
Dec 2, 1999·JAMA : the Journal of the American Medical Association·L S SimonG S Geis
Apr 1, 1965·Arthritis and Rheumatism·J R DEANDRADE, P A CASAGRANDE
Jun 25, 1949·Journal of the American Medical Association·O STEINBROCKERR C BATTERMAN
Oct 1, 1998·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·J F Fries

❮ Previous
Next ❯

Citations

Apr 20, 2005·Journal of Gastroenterology and Hepatology·Stephen N WongSol Z Alvarez
Sep 4, 2004·Annals of the Rheumatic Diseases·L S LohmanderUNKNOWN STAR Multinational Study Group
Jun 27, 2002·Expert Opinion on Investigational Drugs·Richard J Misischia, Larry W Moreland
Jul 11, 2008·Expert Opinion on Drug Safety·Denis A PoddubnyyJoachim Sieper
May 12, 2009·Annals of Medicine·Richard H HuntCarmelo Scarpignato
Sep 12, 2009·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·UNKNOWN American Geriatrics Society Panel on the Pharmacological Management of Persistent Pain in Older Persons
Sep 2, 2004·Alimentary Pharmacology & Therapeutics·J L GoldsteinK M Verburg
Dec 21, 2006·Journal of Clinical Pharmacy and Therapeutics·L-C Chen, D M Ashcroft
Jun 24, 2004·The Annals of Pharmacotherapy·Ryan B Jacobsen, Beth Bryles Phillips
May 13, 2004·Journal of Pharmaceutical and Biomedical Analysis·Hassan JalalizadehAbbas Shafiee
Apr 15, 2005·Emergency Medicine Clinics of North America·Grant D Innes, Peter J Zed
Dec 27, 2005·Drug Discovery Today·Robert J Smith
Jul 25, 2006·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Zaher A Radi, Nasir K Khan
Feb 12, 2010·The Journal of International Medical Research·E Cardenas-EstradaT El-Usseini
Jan 18, 2005·The Journal of International Medical Research·F BerenbaumV S Sloan
Feb 7, 2002·Pharmacoepidemiology and Drug Safety
Jun 10, 2017·The Cochrane Database of Systematic Reviews·Mahir FidahicLivia Puljak
May 23, 2015·The Cochrane Database of Systematic Reviews·Pierre LangevinTed Haines
Jul 3, 2004·Journal of Clinical Gastroenterology·Stuart I HarrisRichard C Hubbard
May 23, 2015·The Cochrane Database of Systematic Reviews·Paul Michael J PelosoUNKNOWN Cervical Overview Group
Nov 3, 2006·American Journal of Physical Medicine & Rehabilitation·Todd P StitikPatrick M Foye
Apr 26, 2007·Pharmacoepidemiology and Drug Safety·Li-Chia Chen, Darren M Ashcroft
May 29, 2007·Arthritis and Rheumatism·Elham RahmeJacques Lelorier

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.