Abstract
Hyperuricemia and gout are common complications of heart transplantation, reaching a prevalence of 84% and 30%, respectively, in heart transplant recipients. In contrast, they are seldom reported following orthotopic liver transplantation (OLT). We retrospectively evaluated 75 consecutive liver transplant recipients and 47 consecutive heart transplant recipients, followed for at least 3 years after transplantation in a single transplantation center in Jerusalem, Israel. Data was collected on demographic and clinical variables, levels of uric acid, the occurrence of gout, renal function, and variables effecting hyperuricemia, such as weight and medications. Clinical gout was significantly more prevalent in heart recipients than in liver recipients (25.5% and 2.6%, respectively). Hyperuricemia was present in 100% of heart recipients, with an average uric acid level of 451 micromol/l, as compared with 85.7% and 403 micromol/l for liver recipients (P < 0.001 for both variables). Univariate analysis identified several parameters which significantly influenced the difference in hyperuricemia and gout among the two groups including age, gender, rejection episodes, hypertension, diabetes mellitus, the level of uric acid prior to transp...Continue Reading
References
Feb 1, 1992·The American Journal of Medicine·D A BurackL E Kahl
May 1, 1990·The American Journal of Medicine·D FargeA Carpentier
May 1, 1990·The American Journal of Medicine·N L Gottlieb
Aug 3, 1989·The New England Journal of Medicine·H Y LinI H Fox
Sep 1, 1989·The American Journal of Medicine·L E KahlB P Griffith
Dec 1, 1994·The Journal of Pediatrics·J LaineC Holmberg
May 15, 1997·Transplantation·J P van Hooff
May 15, 1997·Transplantation·G IppolitiM Vigano
Jul 3, 1998·British Journal of Rheumatology·F Perez-RuizJ Duruelo
Jun 17, 2000·Transplantation Proceedings·G SaharB A Vidne
Oct 25, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·A E WlukaD S Esmore
Sep 18, 2001·Lancet·H J SchlittJ Klempnauer
Dec 1, 2001·Transplantation·D A NealG J Alexander
Dec 1, 2001·Transplantation·H L PilmoreI Dittmer
Citations
Jul 9, 2005·Skeletal Radiology·Patrick C ChangJessica B Chan
Sep 2, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Giuseppina SpartàThomas J Neuhaus
Dec 13, 2005·Transplantation·Kevin C AbbottSophie Caillard
Dec 26, 2009·Current Opinion in Rheumatology·Tony C Ning, Robert T Keenan
Feb 3, 2011·Current Opinion in Rheumatology·Jasvinder A SinghJoseph Kundukulam
Oct 1, 2008·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Jenny Tien DiepSukru Emre
Jun 11, 2010·Best Practice & Research. Clinical Rheumatology·Pascale SchwabGail S Kerr
Jun 10, 2008·Pediatric Transplantation·Jérôme HarambatPierre Cochat
Aug 17, 2006·Pediatric Transplantation·Gokhan TumgorSema Aydogdu
Nov 23, 2006·Clinics in Dermatology·Gerald F Falasca
Sep 5, 2019·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Yeye ZhuoDe Cai
Jun 3, 2021·Medicina·Adla B HassanAmgad E El-Agroudy