Reduced Inhibitory Control Mediates the Relationship Between Cortical Thickness in the Right Superior Frontal Gyrus and Body Mass Index.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Luca LavagninoJair C Soares

Abstract

Unhealthy eating behaviors often develop in the setting of inadequate inhibitory control, a function broadly ascribed to the prefrontal cortex (PFC). Regulation of inhibitory control by the PFC and its anatomical components and their contribution to increasing body mass index (BMI) are poorly understood. To study the role of PFC in the regulation of inhibitory control and body weight, we examined measures of cortical thickness in PFC sub-regions, inhibitory control (color-word interference task (CWIT)), and BMI in 91 healthy volunteers. We tested the predictive effect of PFC sub-regional cortical thickness on BMI and mediation by inhibitory control measured with CWIT. Measures of depression (BDI-II), anxiety (STAI-T) and trauma-related symptoms (TSC-40) were collected; the disinhibition scale of the three-factor eating questionnaire (TFEQ) was used to assess disinhibited eating. We then tested the relationship between BD-II, STAI-T, TSC-40, TFEQ, CWIT, and BMI with correlation analyses. Right superior frontal gyrus cortical thickness significantly predicted BMI (β=-0.91; t=-3.2; p=0.002). Mediation analysis showed a significant indirect effect of cortical thickness on BMI mediated by inhibitory control (95% CI=-6.1, -0.67). BMI...Continue Reading

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Citations

May 20, 2017·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Robert P Fellows, Maureen Schmitter-Edgecombe
Jun 19, 2019·Proceedings of the National Academy of Sciences of the United States of America·Christopher W Kuzawa, Clancy Blair
Oct 28, 2019·Cerebral Cortex·Lisa RonanPaul C Fletcher

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