PMID: 2484419Jan 1, 1989Paper

Reduced intestinal calcium and dietary calcium intake, increased aluminum absorption, and tissue concentration in the rat

Biological Trace Element Research
S D Provan, R A Yokel

Abstract

To test the influence of calcium (Ca) on aluminum (Al) absorption, Ca was withheld from or added (1mM) to the perfusate of the in situ rat gut. The rats had been maintained on Purina Rat Chow. Ca addition significantly decreased (to 70%) the rate of Al disappearance from the gut and decreased (to 55%) the area under the curve of Al appearance in portal blood. To test the influence of Ca deficiency on Al absorption, rats were maintained on a low-Ca (0.008%) or a Ca-replete (0.5%) diet for 1-4 wk. The in situ gut was prepared, and a perfusate containing approximately 1 microM Ca was used. The rate of Al disappearance from the gut of low-Ca diet rats was significantly faster than from the gut of rats maintained on the Ca-replete diet, averaging 156% of the latter. Al appearance in portal blood was significantly greater (averaging 38%) in rats maintained on the low-Ca diet than in controls. To determine if Ca deficiency influences Al tissue distribution independent of gastrointestinal Al absorption, rats maintained on a low-Ca or a Ca-replete diet received 20 ip Al injections over 1 mo. Rats eating the low-Ca diet demonstrated enhanced tissue Al accumulation in all tissues studied, except for muscle and cerebral cortex. These resul...Continue Reading

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Citations

Dec 22, 2007·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Daniel KrewskiVirginie Rondeau
Jan 26, 2010·Brain Research·Benzhong ZhangXiaoling Gao
Jan 7, 1999·Biological Trace Element Research·D ZeyuanC Yifeng
Dec 9, 1998·Biological Trace Element Research·L CunatD Burnel
Jan 1, 1989·Biological Trace Element Research·R A Yokel, P J McNamara
Jan 1, 1997·Pharmacology & Toxicology·D J SánchezJ L Domingo
Jun 4, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yuzhao Zhou, Robert A Yokel
Dec 24, 1997·Critical Reviews in Clinical Laboratory Sciences·J L Greger, J E Sutherland
Sep 2, 2020·Critical Reviews in Toxicology·Robert A Yokel

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