Reduced level of serum cholesterol in low protein-fed Wistar rats administered gossypol and chloroquine

Contraception
P U Nwoha, T A Aire

Abstract

Gossypol and chloroquine were administered in goya oil and distilled water, respectively, to low protein-fed (LP) and normal protein-fed (NP, control) adult male albino Wistar rats for 4 and 8 weeks' duration. Gossypol (GP) and chloroquine (CQ) were administered separately and in combination (GPCQ). At the end of the treatment periods, the rats were anesthetized and blood drawn by cardiac puncture, centrifuged, and sera obtained for assay of total cholesterol and triglycerides levels. The data obtained were analyzed by two-way ANOVA. The results showed that the interaction of GP and CQ in LP and NP-fed rats produced significant effects (P<0.001) on the serum levels of cholesterol and triglycerides. Serum cholesterol level was lower at 8 than at 4 weeks in LP-fed rats but higher at 8 than at 4 weeks in LP fed rats. The administration of GP, CQ, and GPCQ resulted in lower serum cholesterol and triglycerides at 8 than at 4 weeks in LP fed rats but higher serum cholesterol at 4 than at 8 weeks in NP-fed rats. In LP and NP-fed rats, the levels of serum cholesterol and triglycerides were generally lower in GCPQ-treated than GP- or CQ-treated rats. The implications of the findings are discussed.

References

Jun 1, 1975·Journal of Pharmaceutical Sciences·P H DorsettL J Powers
Jul 7, 1988·The New England Journal of Medicine
Jan 7, 1988·The New England Journal of Medicine·B RiouF J Baud
Jul 1, 1986·British Journal of Clinical Pharmacology·S LooareesuwanD A Warrell
Jun 1, 1970·American Heart Journal·T A Don Michael, S Aiwazzadeh
Jan 1, 1971·Annals of Internal Medicine·W B KannelP M McNamara
Apr 21, 1983·The New England Journal of Medicine·D J Wyler
Jan 1, 1983·The American Journal of Occupational Therapy : Official Publication of the American Occupational Therapy Association·J Bair
Jul 1, 1961·The American Journal of Medicine·M J ALBRINKE B MAN

❮ Previous
Next ❯

Citations

Nov 3, 2009·Advances in Food and Nutrition Research·Xi WangYueming Jiang
Jun 1, 2018·Oxidative Medicine and Cellular Longevity·Samar R SalehDoaa A Ghareeb

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.