PMID: 8592650Sep 29, 1995Paper

Reduced long-term potentiation in the dentate gyrus of transgenic mice with cerebral overexpression of interleukin-6

Neuroscience Letters
F P BellingerG R Siggins

Abstract

The cytokine interleukin-6 (IL-6) may be a contributing mediator of CNS injury in several neurological disorders. To investigate the role of IL-6 in memory-related disorders, we examined transgenic mice (GFAP-IL6) with cerebral overexpression of IL-6 using paired-pulse facilitation, paired-pulse inhibition, and long-term potentiation (LTP) in an in vitro preparation. We found that paired-pulse potentiation and inhibition in the dentate gyrus of hippocampal slices prepared from the GFAP-IL6 mice did not differ significantly from age-matched control animals, suggesting that the increase in paired-pulse inhibition seen previously in in vivo studies of this model was due to alterations of afferents from other brain regions. However, LTP in the dentate was significantly reduced in slices from GFAP-IL6 transgenic mice when compared with littermate wild-type controls, providing support for a role of IL-6 in the pathogenesis of neurodegenerative associated memory-related disorders.

References

Sep 1, 1992·Annals of Neurology·E MasliahC A Wiley
Apr 1, 1992·Annals of Neurology·W R TyorD E Griffin
Jun 1, 1991·Acta paediatrica Scandinavica·P GalloL Chieco-Bianchi
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·W S GriffinC Araoz
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·S R KelsoT H Brown
Jun 15, 1987·Neuroscience Letters·G HessL L Voronin
Jan 1, 1980·Pharmacology, Biochemistry, and Behavior·G R Siggins, F E Bloom
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·I L CampbellL Mucke
Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Nov 1, 1949·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·C O HEBB, H KONZETT

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Citations

Feb 11, 1998·Molecular Neurobiology·D L Gruol, T E Nelson
Feb 20, 2009·Acta Neuropathologica·Jasna Kriz, Mélanie Lalancette-Hébert
Sep 1, 2011·Journal of Neural Transmission·Daimei SasayamaHiroshi Kunugi
Jul 22, 2004·Behavioural Brain Research·Daniela BraidaMariaelvina Sala
Feb 10, 2000·Toxicology·D A Lawrence, D Kim
Dec 14, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Bianca De FilippisCarla Fiorentini
Jan 6, 1999·The European Journal of Neuroscience·Y ZhangN Nishiyama
Apr 13, 2000·The European Journal of Neuroscience·G D'ArcangeloF Benfenati
Dec 12, 2012·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Olga BraunStefan Rose-John
Jul 10, 2012·Cerebral Cortex·Peter J GianarosTimothy D Verstynen
Jun 18, 1998·Annals of the New York Academy of Sciences·I L Campbell
Apr 25, 2000·Annual Review of Medicine·W B Ershler, E T Keller
Mar 5, 2010·Molecular Medicine·Michael BacherRichard Dodel
Mar 19, 2013·BMC Psychiatry·Rosa LevandovskiMaria Paz Loayza Hidalgo
Apr 29, 2015·British Journal of Pharmacology·M J Hofer, I L Campbell
Jan 18, 2011·Brain Research Reviews·Anneleen SpoorenSarah Gerlo
Apr 21, 2009·Behavioural Brain Research·Paul Christian BaierThomas Schiffelholz
Jul 6, 2007·The European Journal of Neuroscience·Elly J F VereykenDonna L Gruol
Jan 18, 2012·Journal of Neurochemistry·Sunita GuptaAnnadora J Bruce-Keller
May 28, 2011·The European Journal of Neuroscience·A Cybulska-KlosowiczJ Skangiel-Kramska
May 19, 2010·Journal of Neurochemistry·Romina M UrangaJeffrey N Keller
Apr 12, 2008·The American Journal of Pathology·Salim S El-AmouriMark S Kindy
Sep 3, 2004·Journal of Neuroimmunology·Shannon M ConroyDonna L Gruol
Jun 27, 2006·Neurobiology of Aging·Kristyn A BatesAlan R Harvey
Dec 3, 2014·Neuropharmacology·Annamaria Vezzani, Barbara Viviani
Oct 20, 2009·Biochimica Et Biophysica Acta·Iain L CampbellAxel Pagenstecher
Nov 4, 2000·Expert Opinion on Investigational Drugs·M HüllB L Fiebich
Dec 3, 2014·Neuropharmacology·Donna L Gruol
Apr 9, 2015·Frontiers in Pharmacology·Michal BajoMarisa Roberto

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