Reduced mean platelet volume is associated with poor prognosis in esophageal cancer

Cancer Biomarkers : Section a of Disease Markers
Wenjie ShenRui-Tao Wang

Abstract

Esophageal cancer (EC) is the sixth most common cause of death from cancer. Altered mean platelet volume (MPV) levels were found in patients with malignancies. The present study investigated whether MPV can predict the survival in EC patients. The clinical data of 236 consecutive EC patients between January 2009 and December 2009 in our center were retrospectively analyzed. The overall survival rate was estimated using Kaplan-Meier method. Cox proportional hazards models were fitted to model the relationships between patient characteristics and prognosis. Decreased MPV was significantly correlated with tumor location and tumor differentiation (p< 0.001). Moreover, survival analysis revealed that the overall survival of patients with MPV ⩽ 7.4 fL was significantly shorter than that of those with MPV > 7.4 fL. Multivariate analysis identified MPV as an independent poor prognostic factor for overall survival. Reduced MPV is associated with worse survival outcome in EC.

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Citations

Mar 5, 2019·Cancer Biomarkers : Section a of Disease Markers·Xiaomin ZuoWei Chen
Oct 30, 2020·Cancer Management and Research·Marta MasternakKrzysztof Giannopoulos

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