Reduced membranous and ectopic cytoplasmic expression of DSC2 in esophageal squamous cell carcinoma: an independent prognostic factor

Human Pathology
Wang-Kai FangLi-Yan Xu

Abstract

Desmocollin 2, a desmosomal component, is a key membrane glycoprotein critically involved in cell-cell adhesion and the maintenance of normal tissue architectures in epithelia. Reports exploring the link of desmocollin expression to cancers are limited. The aim of this study was to investigate the expression of desmocollin 2 in esophageal squamous cell carcinoma and, in particular, to determine the extent to which the patterns of desmocollin 2 expression correlated with the clinical parameters. Desmocollin 2 expression was evaluated in 308 cases of esophageal squamous cell carcinoma using immunohistochemistry. Western blotting and reverse transcriptase polymerase chain reaction were performed to characterize the relative expression levels of desmocollin 2 isoforms. The results indicated that desmocollin 2 expression was reduced significantly in esophageal cancer in both protein and messenger RNA levels and that this reduction was associated with poor survival (P = .011). The expression of desmocollin 2 was prominent in normal esophageal epithelia and highly differentiated esophageal tumors, but was reduced or absent in poorly differentiated tumor specimens. Furthermore, in 74.7% of tumor tissues, desmocollin 2 immunoreactivity ...Continue Reading

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Citations

Aug 27, 2013·International Journal of Colorectal Disease·Silke SchüleAnnelore Altendorf-Hofmann
Jun 11, 2014·World Journal of Gastroenterology : WJG·Wang-Kai FangEn-Min Li
Apr 17, 2020·Journal of Cellular and Molecular Medicine·Chenyu GuanYujie Liang
Feb 27, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Wang-Kai FangEn-Min Li
Mar 27, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kathleen ConwayTheresa Swift-Scanlan
Nov 19, 2020·Cancer Management and Research·Feng Jiang, Pengfei Wu

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