Reduced Modulation of Task-Related Connectivity Mediates Age-Related Declines in Bimanual Performance.

Cerebral Cortex
T S MonteiroS P Swinnen

Abstract

Aging is accompanied by marked changes in motor behavior and its neural correlates. At the behavioral level, age-related declines in motor performance manifest, for example, as a reduced capacity to inhibit interference between hands during bimanual movements, particularly when task complexity increases. At the neural level, aging is associated with reduced differentiation between distinct functional systems. Functional connectivity (FC) dedifferentiation is characterized by more homogeneous connectivity patterns across various tasks or task conditions, reflecting a reduced ability of the aging adult to modulate brain activity according to changing task demands. It is currently unknown, however, how whole-brain dedifferentiation interacts with increasing task complexity. In the present study, we investigated age- and task-related FC in a group of 96 human adults across a wide age range (19.9-74.5 years of age) during the performance of a bimanual coordination task of varying complexity. Our findings indicated stronger task complexity-related differentiation between visuomotor- and nonvisuomotor-related networks, though modulation capability decreased with increasing age. Decreased FC modulation mediated larger complexity-relate...Continue Reading

References

Jun 1, 1996·Computers and Biomedical Research, an International Journal·R W Cox
May 4, 2000·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·L R WishartN J Hodges
Sep 14, 2000·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·D J SerrienG E Stelmach
Nov 25, 2000·Experimental Aging Research·J H Yan
Jan 5, 2002·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Caroline J KetchamGeorge E Stelmach
Apr 9, 2005·Journal of the American Geriatrics Society·Ziad S NasreddineHoward Chertkow
Feb 4, 2006·Human Brain Mapping·Tom JohnstoneTerrence R Oakes
Jun 14, 2006·Journal of Cognitive Neuroscience·M RaemaekersN F Ramsey
Sep 14, 2006·Annual Review of Psychology·David P MacKinnonMatthew S Fritz
Oct 10, 2006·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·M E J Newman
Dec 8, 2007·Cerebral Cortex·J S DamoiseauxS A R B Rombouts
Aug 5, 2008·Neurobiology of Aging·Fabio SambataroVenkata S Mattay
Sep 27, 2008·Neuron·Tor D WagerKevin N Ochsner
Jun 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·I DaubechiesJ Haxby
Oct 24, 2009·Neuroscience and Biobehavioral Reviews·Rachael D SeidlerDavid B Lipps
Nov 28, 2009·Neuropsychologia·Ashley S BangertRachael D Seidler
Jan 19, 2010·Cerebral Cortex·James P CoxonStephan P Swinnen
Feb 16, 2010·NeuroImage·G VaroquauxB Thirion
May 4, 2010·NeuroImage·David J MaddenRoberto Cabeza
May 18, 2010·Neurobiology of Aging·Nancy A Dennis, Roberto Cabeza
Jul 19, 2011·Information Processing in Medical Imaging : Proceedings of the ... Conference·Gael VaroquauxBertrand Thirion
Aug 23, 2011·PloS One·Helene M SistiStephan P Swinnen
Oct 8, 2011·NeuroImage·Mark JenkinsonStephen M Smith
Aug 24, 2012·Human Brain Mapping·Linda GeerligsMonicque M Lorist
Jan 22, 2013·Neuroscience and Biobehavioral Reviews·Luiz Kobuti Ferreira, Geraldo F Busatto
Jun 25, 2013·NeuroImage·Jessica A BernardRachael D Seidler
Sep 3, 2013·NeuroImage·Jonathan D PowerSteven E Petersen
Nov 22, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yuzheng HuYihong Yang
Jan 3, 2014·Human Brain Mapping·Linda GeerligsMonicque M Lorist
Jan 24, 2014·Human Brain Mapping·Elena Solesio-JofreStephan P Swinnen
Mar 7, 2014·Neuroscience and Biobehavioral Reviews·Jessica A Bernard, Rachael D Seidler
May 13, 2014·Frontiers in Neuroinformatics·Brian B AvantsJames C Gee
Nov 5, 2014·Proceedings of the National Academy of Sciences of the United States of America·Micaela Y ChanGagan S Wig
Jul 30, 2015·NeuroImage·D VatanseverE A Stamatakis
Sep 2, 2015·Proceedings of the National Academy of Sciences of the United States of America·Urs BraunDanielle S Bassett
Jan 7, 2016·Frontiers in Aging Neuroscience·Christian LaVivek Prabhakaran
Sep 3, 2016·Medical Image Analysis·David ParkerQolamreza R Razlighi

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