Reduced mortality risk by a polyphenol-rich diet: An analysis from the Moli-sani study

Nutrition
George PounisMoli-sani Investigators

Abstract

The effect of the polyphenol content of the human diet on mortality risk is not yet fully understood. The aim of this study was to evaluate the association of a polyphenol-rich diet with mortality rate and a possible mediation effect by inflammation, in what we believe to be a novel, holistic approach. We analyzed 21 302 participants (10 980 women and 10 322 men, aged ≥35 y) from the Moli-sani cohort. The participants were followed up for a median of 8.3 y. The European Prospective Investigation into Cancer and Nutrition food frequency questionnaire (FFQ) was used for dietary assessment. Flavonol, flavone, flavanone, flavanol, anthocyanin, isoflavone, and lignan intakes were calculated using European Food Information Resource-Bioactive Substances in Food Information Systems and the polyphenol antioxidant content (PAC)-score was constructed to assess the total content of these nutrients in the diet. Participants included in the highest quintile of intake of various polyphenol classes and subclasses presented a significant lower all-cause mortality risk compared with those in the lowest group of consumption (hazard ratio [HR] < 1; P <0.05). Cox regression analyses adjusted for potential confounders indicated that participants in ...Continue Reading

Citations

Dec 19, 2018·The Proceedings of the Nutrition Society·F FavaK M Tuohy
Nov 14, 2019·Critical Reviews in Food Science and Nutrition·Vidmantas BendokasJulius Liobikas
Dec 11, 2019·Journal of Cachexia, Sarcopenia and Muscle·Markus S AnkerStephan von Haehling
Oct 15, 2019·Current Pharmaceutical Design·Cíntia R BallardMário R Maróstica
Mar 12, 2020·Nutrition & Dietetics : the Journal of the Dietitians Association of Australia·Arpita DasVasant Hirani
Oct 17, 2020·Oxidative Medicine and Cellular Longevity·Andy W C ManNing Xia
Apr 20, 2021·Toxicological Research·Stephen SafeRupesh Shrestha
Jul 3, 2021·Nutrients·Ligia J DominguezMario Barbagallo

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