Reduced motor cortical inhibition in migraine: A blinded transcranial magnetic stimulation study

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
J P NeverdahlT Sand

Abstract

To investigate motor cortical excitability, inhibition, and facilitation with navigated transcranial magnetic stimulation (TMS) in migraine in a blinded cross-sectional study. Resting motor threshold (RMT), cortical silent period (CSP), short-interval intracortical inhibition (SICI), and intracortical facilitation (ICF) were compared in 27 interictal migraineurs and 33 controls. 24 female interictal migraineurs and 27 female controls were compared in subgroup analyses. Seven preictal migraineurs were also compared to the interictal group in a hypothesis-generating analysis. Investigators were blinded for diagnosis during recording and analysis of data. SICI was decreased in interictal migraineurs when compared to healthy controls (p=0.013), CSP was shortened in female interictal migraineurs (p=0.041). ICF was decreased in preictal compared to interictal migraineurs (p=0.023). RMT and ICF were not different between interictal migraineurs and controls. Cortical inhibition was decreased in migraineurs between attacks, primarily in a female subgroup, indicating an importance of altered cortical inhibition in migraine. Previous studies on motor cortical excitability in migraineurs have yielded varying results. This relatively large ...Continue Reading

Citations

Nov 30, 2018·Journal of Cellular Biochemistry·Abouzar BagheriSayed Mostafa Hosseini
Aug 11, 2018·The Journal of Headache and Pain·Giuseppe CosentinoFilippo Brighina
Oct 30, 2020·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Ignacio Elizagaray-GarciaAlfonso Gil-Martínez
Nov 18, 2021·Cephalalgia : an International Journal of Headache·Jan Petter NeverdahlPetter Moe Omland

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