Jan 1, 1975

Reduced myocardial ATP and creatine phosphate in diabetes: role of 2,3-diphosphoglycerate

Recent Advances in Studies on Cardiac Structure and Metabolism
T B AllisonR S Eliot

Abstract

Observations are presented which suggest that myocardial cellular hypoxia may account for the reduction in myocardial ATP and CP in the ketoacidotic diabetic state. It is suggested that reduced 2,3-diphosphoglycerate adversely affects oxygen release from the red blood cell, thereby leading to myocardial cellular hypoxia.

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Mentioned in this Paper

Neoton
Dioxygen
Phosphocreatine
Myocardium
Cardiomyopathies
Diphosphoglyceric Acids
Blood
Streptozotocin Diabetes
Novolin
Heart

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