Reduced neurobehavioral impairment from sleep deprivation in older adults: contribution of adenosinergic mechanisms.

Frontiers in Neurology
H P LandoltM Adam

Abstract

A night without sleep is followed by enhanced sleepiness, increased low-frequency activity in the waking EEG, and reduced vigilant attention. The magnitude of these changes is highly variable among healthy individuals. Findings in young men of low and high subjective caffeine sensitivity suggest that adenosinergic mechanisms contribute to inter-individual differences in sleep deprivation-induced changes in EEG theta activity, as well as optimal performance on the psychomotor vigilance task (PVT). In comparison to young subjects, healthy adults of older age typically feel less sleepy after sleep deprivation, and show fewer response lapses, and faster reaction times on the PVT, especially in the morning after the night without sleep. We hypothesized that age-related changes in adenosine signal transmission underlie reduced vulnerability to sleep deprivation in older individuals. To test this hypothesis, the combined effects of prolonged wakefulness and the adenosine receptor antagonist, caffeine, on an antero-posterior power gradient in EEG theta activity and PVT performance were analyzed in healthy older and caffeine-insensitive and -sensitive young men. The results show that age-related differences in sleep loss-induced changes...Continue Reading

Citations

Sep 27, 2014·Journal of Sleep Research·Derk-Jan Dijk
May 27, 2014·Journal of Theoretical Biology·Sridhar RamakrishnanJaques Reifman
Dec 4, 2014·Autonomic Neuroscience : Basic & Clinical·Fernando E SantiagoDaniel C Carrettiero
Mar 12, 2015·Journal of Psychopharmacology·Rébecca RobillardJulie Carrier
Jan 13, 2017·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Arcady A Putilov, Olga G Donskaya
Jul 12, 2016·Sleep·Sridhar RamakrishnanJaques Reifman
Jul 25, 2019·Current Pharmaceutical Design·Sumit JamwalAmal Al-Aboudi
Nov 22, 2018·Clocks & Sleep·Susanne WeigendHans-Peter Landolt
Nov 26, 2020·Physiological Measurement·Arcady A PutilovVladimir B Dorokhov

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