Reduced Neuronal Transcription of Escargot , the Drosophila Gene Encoding a Snail-Type Transcription Factor, Promotes Longevity

Frontiers in Genetics
Alexander V SymonenkoElena G Pasyukova

Abstract

In recent years, several genes involved in complex neuron specification networks have been shown to control life span. However, information on these genes is scattered, and studies to discover new neuronal genes and gene cascades contributing to life span control are needed, especially because of the recognized role of the nervous system in governing homeostasis, aging, and longevity. Previously, we demonstrated that several genes that encode RNA polymerase II transcription factors and that are involved in the development of the nervous system affect life span in Drosophila melanogaster. Among other genes, escargot (esg) was demonstrated to be causally associated with an increase in the life span of male flies. Here, we present new data on the role of esg in life span control. We show that esg affects the life spans of both mated and unmated males and females to varying degrees. By analyzing the survival and locomotion of the esg mutants, we demonstrate that esg is involved in the control of aging. We show that increased longevity is caused by decreased esg transcription. In particular, we demonstrate that esg knockdown in the nervous system increased life span, directly establishing the involvement of the neuronal esg function...Continue Reading

References

Aug 1, 1993·Genetical Research·P R HoldenJ F Brookfield
Sep 6, 2000·Proceedings. Biological Sciences·J H Werren, D M Windsor
Mar 29, 2001·Trends in Genetics : TIG·M ManzanaresM A Nieto
Feb 21, 2003·Current Opinion in Neurobiology·James B Skeath, Stefan Thor
Nov 19, 2003·Mechanisms of Development·Andreas Wodarz, Wieland B Huttner
Feb 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yi Zhong, Chun-Fang Wu
Mar 24, 2004·Current Opinion in Microbiology·Elizabeth A McGraw, Scott L O'Neill
Aug 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Horng-Dar WangSeymour Benzer
Sep 24, 2004·Aging Cell·Elena G PasyukovaTrudy F C Mackay
Dec 28, 2004·Ageing Research Reviews·Angela L Ridgel, Roy E Ritzmann
Jan 18, 2005·Genetics·Daria S Hekmat-ScafeMark A Tanouye
Dec 23, 2006·Development·Leonie Ringrose, Renato Paro
Feb 3, 2007·Science·Sergiy LibertScott D Pletcher
Feb 27, 2007·Cell·Bernd SchuettengruberGiacomo Cavalli
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jae Young KwonJohn R Carlson
Jun 3, 2009·Mechanisms of Ageing and Development·Hervé TricoireVéronique Monnier
Apr 28, 2010·PLoS Biology·Peter C PoonScott D Pletcher
Aug 6, 2010·PLoS Genetics·Michael M MagwireTrudy F C Mackay
Oct 23, 2010·Nucleic Acids Research·Steven M GalloMarc S Halfon
Dec 24, 2010·Science·UNKNOWN modENCODE ConsortiumManolis Kellis
Oct 12, 2011·Annual Review of Cell and Developmental Biology·Oliver Hobert
Nov 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marion HartlIlona C Grunwald Kadow
Aug 8, 2012·Nature Reviews. Genetics·François Spitz, Eileen E M Furlong
Mar 12, 2013·Molecular Cell·Eliezer Calo, Joanna Wysocka
Apr 10, 2013·International Journal of Molecular Sciences·Alena Pance
Mar 13, 2014·Frontiers in Immunology·Dev Bhatt, Sankar Ghosh
Mar 26, 2014·Cell Calcium·Latha MukundaDieter Wicher
May 6, 2014·Cell Reports·Justin VoogD Leanne Jones
Apr 4, 2015·Autophagy·Louis R LapierreMalene Hansen
Jul 3, 2015·Invertebrate Reproduction & Development·Heinrich Jasper

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Methods Mentioned

BETA
transgenic
PCR
nucleosome shift

Software Mentioned

CFX Manager

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