Reduced nitric oxide synthase 2 (NOS2) promoter activity in the Syrian hamster renders the animal functionally deficient in NOS2 activity and unable to control an intracellular pathogen

The Journal of Immunology : Official Journal of the American Association of Immunologists
Luis E PerezPeter C Melby

Abstract

Progressive disease in the hamster model of visceral leishmaniasis, caused by Leishmania donovani, in contrast to infection in mice, mimics the progressive disease observed in untreated humans. During progressive infection in hamsters, there was a vigorous type 1 cellular immune response, which is typically associated with control of infection, suggesting that there was ineffective IFN-gamma-mediated macrophage activation. Indeed, at the site of infection, hamsters did not express NO synthase 2 (NOS2), which is the primary mechanism for control of infection in mice. Furthermore, in striking contrast to mouse macrophages, IFN-gamma-activated hamster macrophages did not did not express NOS2 nor generate NO, and were unable to restrict the replication of intracellular L. donovani. The absent hamster NOS2 expression was not the result of NOS2 gene deletion and the NOS2 cDNA had an intact open reading frame. Furthermore, the impaired transcription of NOS2 mRNA was selective and not due to global impairment of IFN-gamma signaling (members of the IFN-gamma-signaling pathway were expressed and functional and IFN-gamma up-regulated several primary and secondary response genes). Strikingly, the proximal hamster NOS2 promoter, like the hu...Continue Reading

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Citations

Jul 14, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Angamuthu SelvapandiyanHira L Nakhasi
Mar 1, 2007·Journal of Leukocyte Biology·Markus Schneemann, Gabriele Schoeden
Dec 6, 2006·Immunology and Cell Biology·Amanda C Stanley, Christian R Engwerda
Mar 19, 2008·Infection and Immunity·Blaise DondjiMichael Cappello
Apr 6, 2013·Revista Da Sociedade Brasileira De Medicina Tropical·Pradyot Bhattacharya, Nahid Ali
Feb 21, 2014·Revista Do Instituto De Medicina Tropical De São Paulo·Elsy Nalleli Loría-Cervera, Fernando José Andrade-Narváez
Jul 1, 2020·Parasite Immunology·Sheetal Saini, Ambak Kumar Rai
Jun 11, 2020·Parasites & Vectors·Alba Martínez-FlórezAlhelí Rodríguez-Cortés
Dec 8, 2020·Frontiers in Immunology·Philippe SaasThomas Cherrier
Mar 9, 2021·Frontiers in Cellular and Infection Microbiology·Mukesh SamantPrashant Khare
Mar 3, 2007·Journal of Leukocyte Biology·Markus Schneemann, Gabriele Schoeden
Nov 16, 2021·Frontiers in Microbiology·Yun-Fu ChenZhao-Rong Lun
May 31, 2011·Free Radical Biology & Medicine·Tim Van AsschePaul Cos
Nov 23, 2021·Frontiers in Immunology·Caroline Vilas Boas de MeloWashington L C Dos-Santos

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