Reduced NK cell IFN-γ secretion and psychological stress are independently associated with herpes zoster

PloS One
Choon Kwan KimEung-Soo Hwang

Abstract

The pathogenesis of herpes zoster is closely linked to reduced varicella-zoster virus-specific cell-mediated immunity. However, little is known about the interplay between natural killer cells and psychological stress in the pathogenesis of herpes zoster. This study aimed to investigate possible associations among natural killer cells, T cells and psychological stress in herpes zoster. Interferon-gamma secretion from natural killer cell, psychological stress events, stress cognition scale scores and cytomegalovirus-specific cell-mediated immunity were compared between 44 patients with herpes zoster and 44 age- and gender-matched control subjects. A significantly lower median level of interferon-gamma secreted by natural killer cells was observed in patients with a recent diagnosis of herpes zoster than in control subjects (582.7 pg/ml vs. 1783 pg/ml; P = 0.004), whereas cytomegalovirus-specific cell-mediated immunity was not associated with herpes zoster. Psychological stress events and high stress cognition scale scores were significantly associated in patients with herpes zoster (P<0.001 and P = 0.037, respectively). However, reduced interferon-gamma secretion from natural killer cell and psychological stress were not associa...Continue Reading

References

Nov 1, 1990·Journal of the American Geriatrics Society·K SchmaderH J Cohen
Apr 15, 1982·International Journal of Cancer. Journal International Du Cancer·H F Pross, M G Baines
Mar 1, 1993·Journal of Clinical Immunology·M SchedlowskiR E Schmidt
Mar 1, 1993·Journal of Medical Virology·T SaibaraY Yamamoto
Nov 9, 2000·The Journal of Infectious Diseases·S K MehtaD L Pierson
Nov 12, 2002·Nature Immunology·Susan GilfillanMarco Colonna
Jul 15, 2004·Psychological Bulletin·Suzanne C Segerstrom, Gregory E Miller
Jun 30, 2006·Yonsei Medical Journal·Kyung Bong KohSunghee Cho
Mar 23, 2007·Immunity & Ageing : I & a·Sonya VastoGraham Pawelec
Jun 1, 2010·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Myron J LevinLawrence Stanberry
Jun 1, 2010·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Anne A GershonPaul D Griffiths
Sep 3, 2013·The Journal of Allergy and Clinical Immunology·Jordan S Orange
Feb 25, 2014·Biochemical and Biophysical Research Communications·Saet-byul LeeJongsun Kim
Nov 13, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rafael HarpazFang Jun Zhou
Apr 24, 2015·Human Vaccines & Immunotherapeutics·Benson OgunjimiPhilippe Beutels
Jul 6, 2016·Frontiers in Immunology·Iona S SchusterMariapia A Degli-Esposti
Apr 27, 2017·Frontiers in Immunology·Dominik Schmiedel, Ofer Mandelboim

❮ Previous
Next ❯

Citations

Jun 14, 2019·PLoS Pathogens·Tessa Mollie CampbellAllison Abendroth
Sep 22, 2019·The Journal of Dermatology·Hidehito MatsubaraHiroomi Hashizume
Jan 30, 2021·The British Journal of Dermatology·S A J SchmidtM Vestergaard

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA

Software Mentioned

R
GraphPad Prism
SPSS

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

© 2022 Meta ULC. All rights reserved