Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development

Nature
A M RosengardP S Steeg

Abstract

Tumour metastasis is the principal cause of death for cancer patients. We have identified the nm23 gene, for which RNA levels are reduced in tumour cells of high metastatic potential. In this report we identify the cytoplasmic and nuclear Nm23 protein, and show that it also is differentially expressed in metastatic tumour cells. We also find that the human Nm23 protein has sequence homology over the entire translated region with a recently described developmentally regulated protein in Drosophila, encoded by the abnormal wing discs (awd) gene. Mutations in awd cause abnormal tissue morphology and necrosis and widespread aberrant differentiation in Drosophila, analogous to changes in malignant progression. The metastatic state may therefore be determined by the loss of genes such as nm23/awd which normally regulate development.

References

Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·W R Pearson, D J Lipman
Apr 6, 1988·Journal of the National Cancer Institute·P S SteegM E Sobel
Nov 1, 1973·Journal of the National Cancer Institute·H D SouleM Brennan

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Citations

Jan 1, 1996·Cell Motility and the Cytoskeleton·C Aguado-VelascoE R Kuczmarski
Oct 23, 1997·International Journal of Cancer. Journal International Du Cancer·G CipolliniM A Caligo
Jan 7, 2000·Journal of Cellular Physiology·D LombardiM G Paggi
Jul 12, 2002·Archives of Insect Biochemistry and Physiology·Tomohide UnoYasuo Aizono
Jul 1, 1991·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G L Nicolson
Jan 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A de la RosaP S Steeg
Mar 14, 2002·The Journal of Comparative Neurology·Perrine BarraudMarc Landry
Nov 1, 1991·Electrophoresis·H H RasmussenJ Vandekerckhove
Apr 1, 1993·Genes, Chromosomes & Cancer·S C ChandrasekharappaF S Collins
Jan 1, 1993·Clinical & Experimental Metastasis·V L MorrisA F Chambers
Jan 1, 1996·Journal of Cancer Research and Clinical Oncology·X P JiangX F Wu
Jan 1, 1995·Journal of Cancer Research and Clinical Oncology·Y OdaA Roessner
Apr 1, 1997·Diseases of the Colon and Rectum·S NakamoriT Irimura
Aug 1, 1997·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·G OhshioH Yamabe
Jan 16, 2002·Breast Cancer : the Journal of the Japanese Breast Cancer Society·N T UenoM C Hung
Feb 22, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Tien Hsu
Sep 1, 2006·Journal of Bioenergetics and Biomembranes·Elayne Provost, Allen Shearn
Sep 1, 2006·Journal of Bioenergetics and Biomembranes·Diane PalmieriPatricia S Steeg
Apr 18, 2009·Molecular and Cellular Biochemistry·Maja Herak BosnarHelena Cetković
Apr 24, 2009·Molecular and Cellular Biochemistry·Sarah J Annesley, Paul R Fisher
Apr 18, 2009·Molecular and Cellular Biochemistry·Gouthami NallamothuTien Hsu
May 6, 2009·Molecular and Cellular Biochemistry·Jong Heun LeeChristine E Horak
Jan 1, 1990·Molecular Aspects of Medicine·T N Dear, R F Kefford
Jan 1, 1992·Pharmacology & Therapeutics·G A Gentry
Feb 1, 1992·Trends in Pharmacological Sciences·M L Lacombe, K H Jakobs
Mar 1, 1995·Molecular and Biochemical Parasitology·R M UlloaM T Tellez-Iñón

❮ Previous
Next ❯

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