PMID: 11897845Mar 19, 2002Paper

Reduced NR2A expression and prolonged decay of NMDA receptor-mediated synaptic current in rat vagal motoneurons following axotomy

The Journal of Physiology
J NabekuraMasayoshi Okada

Abstract

To elucidate characteristic changes in the N-methyl-D-aspartate (NMDA) receptor on neurons following axotomy, subunit expressions and functional features of the NMDA receptor were examined in the dorsal motor nucleus of vagus (DMV) of rats receiving vagal axotomy at the neck. Western blotting analysis demonstrated that the expression of NR2A decreased 2-3 days after in vivo axotomy, while expression of NR1 and NR2B, NR2C and NR2D subunits did not change significantly. To examine the functional changes, patch clamp recordings in whole-cell mode were employed on the axotomized DMV neurons identified by retrograde labelling with fluorescent dye. The amplitude ratios of ifenprodil-sensitive components of NMDA response and D,L-2-amino-5-phosphovaleric acid (APV)-sensitive evoked postsynaptic current increased after axotomy. In addition, APV-sensitive postsynaptic currents exhibited a longer decay time in identified axotomized vagal motoneurons than in control neurons. No significant differences in the current density of the NMDA response and the peak amplitude of APV-sensitive synaptic currents were observed between axotomized and intact DMV neurons. In conclusion, a decrease in NR2A expression results in the appearance of functiona...Continue Reading

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Citations

Dec 26, 2009·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Takao Mukuda, Masaaki Ando
Dec 25, 2008·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Pei ChenShusheng Gong
Feb 8, 2006·Annual Review of Physiology·R Alberto TravagliRichard C Rogers
Mar 22, 2006·The Journal of Cell Biology·Tomoe Y NakamuraJunichi Nabekura
Mar 1, 2005·The European Journal of Neuroscience·Lyndell EleoreCatherine de Waele
Apr 29, 2005·Brain Research. Molecular Brain Research·Isabelle VassiasCatherine de Waele
Nov 3, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Xinyan GaoHaifa Qiao
Mar 26, 2021·JCI Insight·Courtney ClyburnKirsteen N Browning

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