Reduced occipital GABA in Parkinson disease with visual hallucinations

Neurology
Michael J FirbankJohn-Paul Taylor

Abstract

To investigate the relationship between visual hallucinations in Parkinson disease (PD) and levels of γ-aminobutyric acid (GABA) in the primary visual cortex. We utilized magnetic resonance spectroscopy to investigate occipital GABA levels in 36 participants with PD, 19 with and 17 without complex visual hallucinations, together with 20 healthy controls without hallucinations. In addition, we acquired T1-weighted MRI, whole-brain fMRI during a visual task, and diffusion tensor imaging. We found lower GABA+/creatine in PD with visual hallucinations (0.091 ± 0.010) vs those without (0.101 ± 0.010) and controls (0.099 ± 0.010) (F2,49 = 4.5; p = 0.016). Reduced gray matter in the hallucinations group was also observed in the anterior temporal lobe. Although there were widespread reductions in white matter integrity in the visual hallucinations group, this was no longer significant after controlling for cognitive function. The data suggest that reduced levels of GABA are associated with visual hallucinations in PD and implicate changes to the ventral visual stream in the genesis of visual hallucinations. Modulation of visual cortical excitability through, for example, pharmacologic intervention, may be a promising treatment avenue t...Continue Reading

References

Mar 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·A J HughesA J Lees
Jan 1, 1997·Spatial Vision·D H Brainard
Nov 5, 1998·NMR in Biomedicine·M MescherR Gruetter
May 20, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·I TkácR Gruetter
Oct 21, 2000·The British Journal of Psychiatry : the Journal of Mental Science·M P WalkerC G Ballard
Feb 15, 2002·Brain : a Journal of Neurology·A J HardingG M Halliday
Mar 22, 2002·NeuroImage·Jeng-Ren DuannTerrence J Sejnowski
Apr 21, 2006·NeuroImage·Stephen M SmithTimothy E J Behrens
Jun 2, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Murat EmreBruno Dubois
Jan 9, 2008·International Journal of Geriatric Psychiatry·Urs Peter MosimannIan Grant McKeith
Mar 1, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Mariese A HelyJohn G L Morris
Apr 22, 2011·Journal of Magnetic Resonance Imaging : JMRI·Ruth L O'GormanErnst Martin
Sep 29, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Neil K ArchibaldDavid J Burn
Oct 22, 2011·The British Journal of Psychiatry : the Journal of Mental Science·John-Paul TaylorJohn T O'Brien
Jan 26, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Irene LitvanMurat Emre
Apr 14, 2012·The British Journal of Psychiatry : the Journal of Mental Science·John-Paul TaylorJohn T O'Brien
Jul 11, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Richard A E EddenPeter B Barker
Dec 26, 2012·Trends in Cognitive Sciences·Dwight J KravitzMortimer Mishkin
Apr 10, 2013·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Joshua S WoodJohn T O'Brien
Jan 18, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jamie NearPeter Jezzard
Feb 1, 2014·Brain : a Journal of Neurology·Jennifer G GoldmanChristopher G Goetz
Aug 27, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Alana J MullerSimon J G Lewis
Oct 6, 2014·Neural Networks : the Official Journal of the International Neural Network Society·Hiromichi TsukadaIchiro Tsuda
Dec 31, 2014·Journal of Magnetic Resonance Imaging : JMRI·Richard A E EddenC John Evans
May 26, 2015·Current Biology : CB·Claudia LunghiHolly Bridge
Nov 6, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·William SedleyTimothy D Griffiths
Dec 27, 2015·Human Brain Mapping·Michael FirbankJohn-Paul Taylor
Jan 23, 2016·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Prabitha UrwylerUrs Peter Mosimann
Mar 26, 2016·Progress in Neurobiology·Philippe De Deurwaerdère, Giuseppe Di Giovanni
Oct 21, 2016·Neuro-degenerative Diseases·Woong-Woo LeeYu Kyeong Kim
Oct 22, 2016·Parkinsonism & Related Disorders·Julie M HallAhmed A Moustafa
Jan 21, 2017·Nature Reviews. Neurology·Dominic H FfytcheDag Aarsland
Jun 13, 2017·Cognitive Research: Principles and Implications·Alan Robert BowmanDaniel Collerton

❮ Previous
Next ❯

Citations

Nov 14, 2019·Human Brain Mapping·Annelies J M van NulandRick C Helmich
Jul 20, 2018·Neurology·Marco Onofrj, Gordon J Gilbert
May 7, 2020·The Journal of Neuropsychiatry and Clinical Neurosciences·Alice PowellSimon J G Lewis
Apr 24, 2020·International Clinical Psychopharmacology·Siu Wa Tang, Wayne Hans Tang
Jul 16, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Marco OnofrjStefano L Sensi
Dec 7, 2019·Journal of Geriatric Psychiatry and Neurology·Akira KuritaMegumi Suzuki
Jan 11, 2020·Frontiers in Pharmacology·Mirella RussoMarco Onofrj
Dec 4, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Richard J CaselliEric M Reiman
Oct 21, 2020·Brain and Behavior·Natsuko YukiTadashi Kimura
Nov 25, 2020·Current Opinion in Neurology·Ali G Hamedani
Feb 16, 2021·Frontiers in Neurology·Nicholas MurphyPrabitha Urwyler
Feb 7, 2021·Journal of the Neurological Sciences·Yulu SongRichard A E Edden
Mar 13, 2021·The Journal of Neuropsychiatry and Clinical Neurosciences·Michael J YoungFarrah J Mateen
Mar 22, 2021·Magma·Yulu SongRichard A E Edden
Dec 13, 2018·Progress in Nuclear Magnetic Resonance Spectroscopy·Andrew M Blamire
Aug 4, 2021·Der Nervenarzt·Nico J Diederich

❮ Previous
Next ❯

Software Mentioned

Gannet toolbox
Statistical Parametric Mapping ( SPM )
Statistical Package for Social Sciences ( SPSS
dtifit
TBSS ( tract - based spatial statistics )
SPM
MATLAB
SPM12
SPM Anatomy
FSL

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.