Reduced ocular pulse amplitude in low tension glaucoma is independent of vasospasm

Eye
K G SchmidtL E Pillunat

Abstract

A vascular basis for the pathogenesis of primary open angle glaucoma has been postulated for many years. Defects in the regulation of ocular blood flow may be the initiating factor in this group of multifactorial diseases. This study was designed to evaluate the effect of vasospasm on ocular pulse amplitude (OPA) in low tension glaucoma (LTG) patients. OPA, using the Langham Ocular Blood Flow (OBF) System, applanation intraocular pressure (IOP), systemic blood pressure and heart rate were measured and vasospasm was determined by a fingernail capillary blood flow test. OPA (mmHg) in the LTG patients with a vasospastic reaction (LTG-V, 1.4 +/- 0.1, n = 17) was not significantly (p > 0.09) different when compared with non-vasospastic LTG patients (LTG-NV, 1.5 +/- 0.2, n = 15) but was significantly (p < 0.001) reduced in LTG-V and LTG-NV patients when compared with matched healthy control subgroups (2.3 +/- 0.2 and 2.4 +/- 0.3, respectively). IOP (mmHg) in LTG-V (13.3 +/- 0.4) and LTG-NV (13.2 +/- 0.5) patient groups was not significantly (p > 0.05) different when compared with each other, but was significantly (p < 0.05) lower when compared with matched control subgroups (15.0 +/- 0.3 and 15.2 +/- 0.4, respectively). Haemodynamic ...Continue Reading

References

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Citations

Sep 28, 2004·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·K-G Schmidt
Sep 30, 2004·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·R H W Funk, K-G Schmidt
Oct 19, 2004·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·T Mittag, K-G Schmidt
Oct 19, 2004·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·K-G SchmidtN N Osborne
Jan 15, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Chantal VulstekeThierry Zeyen
Jul 21, 2012·International Ophthalmology·Kotaro IshiiTetsuro Oshika
Mar 31, 2004·Experimental Eye Research·Karl-Georg SchmidtT W Mittag
Sep 10, 2002·Ultrasound in Medicine & Biology·Oliver ZeitzMaren Klemm
Dec 15, 2010·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Robert L Stamper
Oct 26, 2000·The British Journal of Ophthalmology·K G SchmidtH P Hammes
Nov 7, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Carlos Gustavo Vasconcelos De MoraesRemo Susanna
Dec 20, 2007·Journal of Glaucoma·Jennifer S WeizerLeon W Herndon
Aug 16, 2008·Journal of Glaucoma·Ingeborg StalmansBrent Siesky
Jul 27, 2010·Optometry : Journal of the American Optometric Association·Dina H EricksonJohn R Hayes
Nov 26, 2008·Survey of Ophthalmology·Christoph KniestedtRobert L Stamper
Apr 28, 2018·The British Journal of Ophthalmology·Clara C CousinsLouis R Pasquale

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