Reduced or absent cyclin H expression is an independent prognostic marker for poor outcome in diffuse large B-cell lymphoma

Human Pathology
Prashant P BaviKhawla S Al-Kuraya

Abstract

Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoid malignancy in adults, accounting for nearly 40% of all non-Hodgkin's lymphomas. As cell proliferation is essential for tumor growth, analysis of the cell cycle might give additional information on tumor progression. Although markers distinctive for cell-cycle regulation in DLBCL have been addressed, less attention has been paid to cyclin H in DLBCL with respect to its prognostic and potential therapeutic implications. Cyclin H occurs as a component of the cyclin H/Cdk 7/Mat 1 complex. Cyclin H is also a substrate of protein kinase 2, a ubiquitously expressed serine/threonine protein kinase required for cell viability and cell-cycle progression. We evaluated the expression of cyclin H by immunohistochemistry in 301 DLBCLs in a tissue microarray format. Validation was done by performing quantitative real-time polymerase chain reaction and Western blotting experiments for cyclin H. We studied the relationship between cyclin H expression in comparison to other cyclins (A, B1, D1, D3, and E) and the proliferation marker Ki-67. Reduced or absent cyclin H expression was seen in 14.5% of the DLBCL cases. Interestingly, reduced or absent cyclin H expression was correlated...Continue Reading

References

Jul 14, 1998·Nature Medicine·J KononenO P Kallioniemi
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Feb 26, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tsutomu MasakiShigeki Kuriyama
Jun 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Masatoshi YamaguchiMasaaki Umeda
Oct 8, 2003·The Journal of Endocrinology·S S GuoM P Sawicki
Jan 27, 2004·The American Journal of Pathology·Ana-Isabel SáezMiguel A Piris
May 28, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Christine P HansJames O Armitage
Dec 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gary K Schwartz, Manish A Shah
Jan 19, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Izidore S Lossos, Daniel Morgensztern
Feb 1, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·F KayaselcukB Demirhan
May 11, 2006·Blood·Francesco A PiazzaGianpietro Semenzato
May 23, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Khawla Al KurayaGuido Sauter

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Citations

Aug 22, 2009·The Journal of Pathology·Zeenath JehanKhawla S Al-Kuraya
Jul 16, 2010·The Journal of Pathology·Azhar R HussainKhawla S Al-Kuraya
Jun 21, 2014·The British Journal of Oral & Maxillofacial Surgery·Abitha MuraliS Kannan
Jan 23, 2016·Reproductive Biomedicine Online·Shirly Lahav-BaratzMartha Dirnfeld
Jul 28, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Rong BuKhawla S Al-Kuraya
Jun 10, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Shahab UddinKhawla S Al-Kuraya
Jul 23, 2020·Cancer Cell International·Chen PengYuquan Zhang

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