Reduced Orbitofrontal Gray Matter Concentration as a Marker of Premorbid Childhood Trauma in Cocaine Use Disorder

Frontiers in Human Neuroscience
Keren BachiNelly Alia-Klein

Abstract

Background: Childhood trauma affects neurodevelopment and promotes vulnerability to impaired constraint, depression, and addiction. Reduced gray matter concentration (GMC) in the mesocorticolimbic regions implicated in reward processing and cognitive control may be an underlying substrate, as documented separately in addiction and for childhood trauma. The purpose of this study was to understand the contribution of childhood maltreatment to GMC effects in individuals with cocaine use disorder. Methods: Individuals with cocaine use disorder were partitioned into groups of low vs. high childhood trauma based on median split of the total score of the Childhood Trauma Questionnaire (CTQ; CUD-L, N = 23; CUD-H, N = 24) and compared with age, race, and gender matched healthy controls with low trauma (N = 29). GMC was obtained using voxel-based morphometry applied to T1-weighted MRI scans. Drug use, depression and constraint were assessed with standardized instruments. Results: Whole-brain group comparisons showed reduced GMC in the right lateral orbitofrontal cortex (OFC) in CUD-H as compared with controls (cluster-level pFWE-corr < 0.001) and CUD-L (cluster-level pFWE-corr = 0.035); there were no significant differences between CUD-L...Continue Reading

References

Jan 1, 1992·Journal of Substance Abuse Treatment·A T McLellanM Argeriou
Nov 1, 1992·British Journal of Addiction·M GossopJ Strang
Mar 1, 1991·Comprehensive Psychiatry·D L DillS V Eisen
Dec 1, 1993·Drug and Alcohol Dependence·S T TiffanyJ E Henningfield
Aug 12, 1998·Addictive Behaviors·K M KampmanL E Epperson
Oct 24, 1998·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·H AnismanZ Merali
Jul 11, 2001·The American Journal on Addictions·J WestermeyerP Thuras
Mar 22, 2002·NeuroImage·Christopher R GenoveseThomas Nichols
Apr 13, 2002·Biological Psychiatry·Michael D De BellisJulie Hall
Jun 12, 2002·Psychological Assessment·Christopher J PatrickAuke Tellegen
Oct 3, 2002·The American Journal of Psychiatry·Rita Z Goldstein, Nora D Volkow
Nov 27, 2002·The American Journal of Psychiatry·Meena VythilingamJ Douglas Bremner
Jan 28, 2003·Nature Neuroscience·Elizabeth R SowellArthur W Toga
Mar 5, 2003·Child Abuse & Neglect·David P BernsteinWilliam Zule
Jun 28, 2003·Neurobiology of Aging·E Ronald de Kloet, Melly S Oitzl
Feb 26, 2004·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Jochen Hardt, Michael Rutter
Mar 3, 2004·Journal of Abnormal Psychology·Sara R JaffeeAlan Taylor
Mar 9, 2004·Child Abuse & Neglect·Christine D ScherMurray B Stein
Jun 16, 2005·NeuroImage·John Ashburner, Karl J Friston
Nov 29, 2005·European Archives of Psychiatry and Clinical Neuroscience·Robert F AndaWayne H Giles
Dec 15, 2005·IEEE Transactions on Medical Imaging·Meritxell Bach CuadraJean-Philippe Thiran
Apr 18, 2006·Biological Psychiatry·Ronald A CohenLeanne M Williams
Feb 15, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Minyoung E SimPerry F Renshaw
Aug 28, 2007·Biological Psychiatry·Geoffrey Schoenbaum, Yavin Shaham
Jan 10, 2008·Assessment·Stijn VanheuleJohnny Fontaine
Jul 3, 2008·The American Journal of Psychiatry·Jana WraseAndreas Heinz
Jul 12, 2008·Neuropharmacology·N D VolkowF Telang
Sep 23, 2008·Metabolism: Clinical and Experimental·Bruce S McEwen
Nov 11, 2008·Annals of the New York Academy of Sciences·Rajita Sinha
Dec 30, 2008·Neuroscience and Biobehavioral Reviews·Andrew Holmes, Cara L Wellman
May 5, 2009·Pharmacology, Biochemistry, and Behavior·Fulton Timm Crews, Charlotte Ann Boettiger
May 21, 2009·Nature Reviews. Neuroscience·Amy F T Arnsten
Aug 7, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jennifer L Whitwell
Dec 1, 2009·NeuroImage·J ChumbleyK Friston
Feb 4, 2010·Journal of Psychiatric Research·Thomas FrodlEva M Meisenzahl
Feb 24, 2010·Journal of Family Psychology : JFP : Journal of the Division of Family Psychology of the American Psychological Association (Division 43)·Steven R H BeachRobert A Philibert
Mar 4, 2010·Drug and Alcohol Dependence·Sunny Hyucksun ShinAndrea L Hazen
Jun 4, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jamie L HansonSeth D Pollak
Aug 3, 2010·The Journal of Clinical Psychiatry·Kathleen ThomaesDick J Veltman

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Citations

Mar 3, 2020·Neuropharmacology·Matteo Di SegniRossella Ventura
Oct 2, 2021·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Romain IcickVanessa Bloch

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Methods Mentioned

BETA
environmental stress

Software Mentioned

FSL
Mathworks Matlab
HCP PreFreeSurfer
SPSS
FreeSurfer
FMRIB
FLIRT
VBM8
FNIRT ( FMRIB
Statistical Parametric Mapping SPM12 SPM8

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