Reduced peripheral blood regulatory B cell levels are not associated with the Expanded Disability Status Scale score in multiple sclerosis

The Journal of International Medical Research
Shujun GuoDaoqian Sang

Abstract

Objective To investigate levels of regulatory B (Breg) cells, plasma cells, and memory B cells in the peripheral blood, and interleukin (IL)-10 in the serum of multiple sclerosis (MS) patients, and to determine the correlation between Breg cell levels and the Expanded Disability Status Scale (EDSS) score. Methods Levels of Breg cells, plasma cells, and memory B cells in the peripheral blood of 12 MS patients were measured using flow cytometry. IL-10 serum levels were measured by enzyme-linked immunosorbent assay. The correlation between Breg cell levels and MS EDSS score was measured using Pearson's correlation coefficient. Results Compared with healthy controls, MS patients had decreased levels of CD19+CD24hiCD38hi Breg cells in their peripheral blood and reduced serum levels of IL-10; however, the ratios of CD19+CD27hiCD38hi plasma cells and CD19+CD27+CD24hi memory B cells to total B cells did not differ significantly between healthy controls and MS patients. CD19+CD24hiCD38hi Breg cell levels in the peripheral blood of MS patients were not significantly correlated with MS EDSS score. Conclusion Peripheral blood CD19+CD24hiCD38hi Breg cell levels and serum IL-10 levels were reduced in MS patients compared with controls, but B...Continue Reading

References

Dec 1, 1996·The Journal of Experimental Medicine·S D WolfC A Janeway
Apr 28, 2000·International Immunology·E MizoguchiA K Bhan
Sep 24, 2002·Nature Immunology·Simon FillatreauStephen M Anderton
Jun 3, 2004·The Journal of Experimental Medicine·David M Tarlinton, Philip D Hodgkin
Jun 2, 2009·Current Opinion in Pharmacology·Shomyseh SanjabiRichard A Flavell
Sep 19, 2009·Journal of Clinical Immunology·Sara A J ThompsonAlasdair J Coles
Nov 26, 2009·Autoimmunity Reviews·Ron Milo, Esther Kahana
Dec 14, 2011·The Journal of Biological Chemistry·Zhanju LiuPing-Chang Yang
Jan 10, 2012·Annual Review of Immunology·Claudia Mauri, Anneleen Bosma
Feb 22, 2013·Science Translational Medicine·Fabian Flores-BorjaClaudia Mauri
Jul 6, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Hannah-Maria HummelJens Wuerfel
Dec 11, 2014·Annals of Clinical and Translational Neurology·Daniel C AnthonyDavid Leppert
Apr 23, 2015·Immunity·Elizabeth C Rosser, Claudia Mauri
Apr 15, 2016·Current Opinion in Neurology·Manuel ComabellaXavier Montalban
Aug 6, 2016·Cellular and Molecular Life Sciences : CMLS·Stefanie JörgMarkus Kleinewietfeld
Jan 6, 2017·Neurology. Neuroimmunology and Neuroinflammation·Alexander SchwarzJürgen Haas
Jul 8, 2017·Brain Sciences·Narges DargahiVasso Apostolopoulos
Jul 20, 2017·Neuropsychiatric Disease and Treatment·Chun LuoYuan Wu

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Citations

Sep 15, 2020·Multiple Sclerosis : Clinical and Laboratory Research·Maria T CencioniPaolo A Muraro
Nov 12, 2018·Auto- Immunity Highlights·Georgios K VasileiadisGeorgios M Hadjigeorgiou
Dec 28, 2019·International Immunopharmacology·Hongxia WuPrince Amoah Barnie

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Methods Mentioned

BETA
flow cytometry
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

SPSS

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