PMID: 15223872Jun 30, 2004Paper

Reduced pH and chloride levels in exhaled breath condensate of patients with chronic cough

Thorax
A NiimiK F Chung

Abstract

Increased hydrogen and reduced chloride ionic environments of the airways are conducive to the stimulation of cough. However, the constituents of the local milieu of the airways of patients with chronic cough are unknown. The pH and chloride levels in exhaled breath condensate and capsaicin cough threshold (C5) were measured in 50 patients with chronic cough and in 16 healthy controls. pH and chloride measurements were repeated after capsaicin challenge in those with cough. The cause of cough was asthma (n = 13), postnasal drip/rhinitis (n = 7), gastro-oesophageal reflux (n = 5), bronchiectasis (n = 5), but remained unidentified in 20. Compared with controls, patients with chronic cough had lower pH (mean 7.9 v 8.3, 95% CI of difference -0.5 to -0.2, p<0.0001), chloride levels (median 4 v 6 mmol/l, 95% CI -3.1 to -0.2, p = 0.007), and C5 (median 3.9 v 125 micro M, 95% CI -270.0 to -17.6, p = 0.002). The pH levels were different in the six subgroups including controls, and were reduced in all diagnostic subgroups of patients with cough compared with controls but did not differ between them. Chloride levels were significantly different in the six subgroups but were lower than controls in only the gastro-oesophageal reflux subgrou...Continue Reading

References

Jul 1, 1990·The American Review of Respiratory Disease·P G VentrescaK F Chung
Feb 1, 1994·American Journal of Respiratory and Critical Care Medicine·L P BouletM Laviolette
Oct 1, 1996·Postgraduate Medical Journal·K F Chung, U G Lalloo
Jul 2, 1998·The European Respiratory Journal·A NiimiF Kuze
Aug 28, 1999·Respiratory Medicine·C H WongA H Morice
Mar 11, 2000·American Journal of Respiratory and Critical Care Medicine·J F HuntB Gaston
Jun 3, 2000·The European Respiratory Journal·L P McGarveyM Ennis
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·S E JordtD Julius
Aug 19, 2000·Lancet·A NiimiR Amitani
Nov 4, 2000·The American Journal of Medicine·T Grodzicky, K B Elkon
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·S A Kharitonov, P J Barnes
Jun 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·S JayaramanA S Verkman
Jan 10, 2002·American Journal of Respiratory and Critical Care Medicine·John F HuntBenjamin Gaston
May 23, 2002·American Journal of Respiratory and Critical Care Medicine·Konstantinos KostikasStelios Loukides
Jun 27, 2002·Expert Opinion on Investigational Drugs·K F Chung
Jul 9, 2002·Pulmonary Pharmacology & Therapeutics·Alyn H Morice
Sep 3, 2002·The Journal of Physiology·Marian Kollarik, Bradley J Undem
Oct 3, 2002·American Journal of Respiratory and Critical Care Medicine·Jack A KastelikAlyn H Morice
Feb 7, 2003·The European Respiratory Journal·D McShaneE W F W Alton

❮ Previous
Next ❯

Citations

Jun 19, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Balazs AntusKrisztina Kelemen
Dec 6, 2011·Lung·M Diane LougheedThomas Fisher
Jul 3, 2007·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Heung-Woo ParkSang-Heon Cho
Jan 17, 2014·The Lancet. Respiratory Medicine·Kian Fan ChungStuart B Mazzone
Mar 29, 2007·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Michael Riediker, Brigitta Danuser
Feb 9, 2005·Current Opinion in Pulmonary Medicine·Richard M EffrosMarshall Dunning
Sep 28, 2004·American Journal of Respiratory and Critical Care Medicine·David A GronebergK Fan Chung
Nov 15, 2005·American Journal of Respiratory and Critical Care Medicine·Richard M EffrosReza Shaker
Jul 27, 2010·American Journal of Respiratory and Critical Care Medicine·Balazs AntusEszter Csiszer
Mar 11, 2008·Environmental Health : a Global Access Science Source·Jill M FerdinandsW Gerald Teague
Feb 27, 2008·Journal of Clinical Biochemistry and Nutrition·Yasuo ShimizuMasatomo Mori
Dec 16, 2011·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Krishna M Sundar, Sarah E Daly
May 9, 2013·Gastroenterology Research and Practice·Ossur Ingi EmilssonIsleifur Olafsson
Sep 13, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Anne M FitzpatrickUNKNOWN American Lung Association's Asthma Clinical Research Centers Network
Oct 8, 2005·Respiration; International Review of Thoracic Diseases·A DavidssonB Schmekel
Mar 10, 2011·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Luis PrietoJulio Marin
Aug 6, 2011·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·S BanovićS Dodig
Jul 12, 2013·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Akio NiimiMitsuru Adachi
Jun 1, 2008·Expert Opinion on Medical Diagnostics·Jodie L Simpson, Peter Ab Wark
Jun 13, 2006·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·P ReinholdC Schroeder
Apr 17, 2008·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Henri KnoblochPetra Reinhold
Nov 20, 2012·Medicina intensiva·L J NanniniG Guelman Greta
Aug 11, 2012·Immunology and Allergy Clinics of North America·Michael D Davis, John Hunt
Feb 16, 2006·Chest·Alix O Paget-BrownJohn F Hunt
Feb 5, 2011·Pulmonary Pharmacology & Therapeutics·Akio Niimi
Nov 10, 2009·Pharmacology & Therapeutics·Khadija Alawi, Julie Keeble
Jan 6, 2009·Pulmonary Pharmacology & Therapeutics·Akio NiimiMichiaki Mishima
Oct 18, 2015·Pulmonary Pharmacology & Therapeutics·Akio Niimi, Kian Fan Chung
Nov 11, 2008·Pulmonary Pharmacology & Therapeutics·Masaya TakemuraDavid A Groneberg
Nov 13, 2007·Immunology and Allergy Clinics of North America·John Hunt
Feb 10, 2007·Pulmonary Pharmacology & Therapeutics·Marian KollarikBradley J Undem
Dec 16, 2006·Pulmonary Pharmacology & Therapeutics·Akio Niimi
Dec 13, 2006·Pulmonary Pharmacology & Therapeutics·K F Chung
Nov 16, 2013·Lung·Krishna M Sundar, Sarah E Daly
Mar 24, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K F Chung
Oct 27, 2007·Pediatric Pulmonology·Christian VogelbergWolfgang Leupold
Jan 14, 2009·Journal of Clinical Laboratory Analysis·Slavica DodigBoro Nogalo
Jun 17, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G VassI Horváth
Feb 16, 2006·Journal of Internal Medicine·G E CarpagnanoM P Foschino-Barbaro
Oct 19, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M TakemuraM Mishima
May 12, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L J DupontG M Verleden
Mar 15, 2006·Respiratory Physiology & Neurobiology·K F Chung
Nov 18, 2005·Pediatric Pulmonology·Ting F LeungGary W K Wong

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

American Journal of Respiratory and Critical Care Medicine
David A GronebergK Fan Chung
American Journal of Respiratory and Critical Care Medicine
Konstantinos KostikasS Loukides
The Journal of Allergy and Clinical Immunology
A NiimiKian Fan Chung
© 2022 Meta ULC. All rights reserved