Reduced Photoreceptor Outer Segment Layer Thickness and Association with Vision in Amblyopic Children and Adolescents with Unilateral High Myopia.

Current Eye Research
Tingkun ShiHaoyu Chen

Abstract

To quantitatively compare reflectivity and other morphological changes of the photoreceptors of normal eyes with amblyopic eyes using the longitudinal reflectance profile (LRP) on swept-source optical coherence tomography (SS-OCT) images in children and adolescents with unilateral high myopia. The relationships between OCT parameters and visual acuity were investigated. Twenty-six amblyopes with unilateral high myopia and 34 age-, axial length- and spherical equivalent-matched normal controls were recruited. All participants underwent SS-OCT and detailed ophthalmic investigations. The reflectivity of the outer retinal and photoreceptor outer segment layer thickness were quantified by LRP using ImageJ software. All parameters were measured at three selected regions: at the fovea, 1 mm nasal to the fovea and 1 mm temporal to the fovea. Differences between the groups were evaluated. The mean choroidal thickness was thinner in amblyopic eyes compared with controls (165.19 ± 59.02 μm vs 214.97 ± 66.41 μm at the fovea; 128.77 ± 57.06 μm vs 161.54 ± 57.37 μm at 1 mm nasal to the fovea; 188.13 ± 59.51 μm vs 219.87 ± 61.78 μm at 1 mm temporal to the fovea, P < .05). The amblyopic eyes had higher reflectivity of the ellipsoid zone at 1 m...Continue Reading

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