PMID: 8592803Nov 1, 1995Paper

Reduced physeal area and chondrocyte proliferation in Pasteurella multocida toxin-treated rats

Veterinary Pathology
M R AckermannJ H Hilton

Abstract

Pasteurella multocida toxin depresses weight gain in rats and pigs. It also affects tissues with rapidly dividing cells. In the present study, we investigated the role of this protein toxin on chondrocyte growth in vivo. Rats were divided into a single- or multiple-dose group and were given, respectively, either a single injection (0.15 or 0.6 micrograms/kg toxin subcutaneously) or multiple injections (0.01-0.2 micrograms/kg subcutaneously) of toxin. Bone (humerus) and other selected tissues were stained for bromodeoxyuridine immunoreactivity (BrDU-IR) in order to gauge cell proliferation. Physeal area was measured in rats from the multiple-dose group. Serum from single- and multiple-dose groups were tested for tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6) activity using a bioassay system. Decreased weight gain, feed intake, and feed efficiency were observed in single- and multiple-dose groups of rats. Decreased BrDU-IR indices were present in the resting and proliferative zone chondrocytes of the humeral physis in rats from the multiple-dose group, as was decreased physeal area. Increased serum IL-6 bioactivity was present in rats after 24 hours, and no changes in TNF-alpha bioactivity were seen in any group...Continue Reading

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Citations

Jul 5, 2013·Clinical Microbiology Reviews·Brenda A Wilson, Mengfei Ho
Oct 27, 2004·Veterinary Microbiology·R W Jordan, J M Roe
Mar 12, 2015·Cellular Microbiology·Markus WeiseJoachim H C Orth

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