Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia

Nature Neuroscience
Andreas Meyer-LindenbergKaren F Berman

Abstract

Both dopaminergic neurotransmission and prefrontal cortex (PFC) function are known to be abnormal in schizophrenia. To test the hypothesis that these phenomena are related, we measured presynaptic dopaminergic function simultaneously with regional cerebral blood flow during the Wisconsin Card Sorting Test (WCST) and a control task in unmedicated schizophrenic subjects and matched controls. We show that the dopaminergic uptake constant Ki in the striatum was significantly higher for patients than for controls. Patients had significantly less WCST-related activation in PFC. The two parameters were strongly linked in patients, but not controls. The tight within-patient coupling of these values, with decreased PFC activation predicting exaggerated striatal 6-fluorodopa uptake, supports the hypothesis that prefrontal cortex dysfunction may lead to dopaminergic transmission abnormalities.

References

Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A GjeddeH Kuwabara
Jul 1, 1987·Archives of General Psychiatry·D R Weinberger
Mar 1, 1983·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C S PatlakJ D Fenstermacher
Aug 1, 1995·Schizophrenia Research·D R Weinberger, Barbara K Lipska
Sep 1, 1995·Journal of Neurochemistry·Paul CummingA Gjedde
Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·J ReithA Gjedde
Jan 1, 1993·Journal of Neural Transmission. General Section·Anthony A Grace
Jul 1, 1993·Journal of Computer Assisted Tomography·R P WoodsSimon R Cherry
Sep 1, 1995·Psychological Medicine·D A Lewis, S A Anderson
Oct 29, 1996·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D R Weinberger, Karen F Berman
Feb 7, 1997·Schizophrenia Research·M H Dao-CastellanaJean-Luc Martinot
Nov 13, 1998·The American Journal of Psychiatry·Anissa Abi-DarghamR Innis
Feb 16, 1999·Schizophrenia Research·Jarmo HietalaR K Salokangas
Jan 29, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alessandro BertolinoD R Weinberger
Feb 10, 2000·Journal of Psychopharmacology·Marc Laruelle, Anissa Abi-Dargham
Jul 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·Anissa Abi-DarghamMarc Laruelle
Aug 25, 2000·Journal of Psychopharmacology·M R Bennett
Nov 25, 2000·Psychiatry Research·A M ElkashefR J Wyatt
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·A CarlssonM L Carlsson

Citations

Apr 5, 2012·Archives of General Psychiatry·Oliver D HowesShitij Kapur
Aug 12, 2005·Science in China. Series C, Life Sciences·Xiangqing SunYanda Li
Jan 19, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Thorsten KienastAndreas Heinz
May 12, 2005·Acta Neuropathologica·Pawel KreczmanskiChristoph Schmitz
Sep 4, 2012·European Archives of Psychiatry and Clinical Neuroscience·C Christoph SchultzRalf G M Schlösser
Oct 27, 2006·Journal of Neural Transmission·K FuxeLuigi F Agnati
Jan 23, 2013·Journal of Pharmacokinetics and Pharmacodynamics·H GeertsRobert Carr
Sep 21, 2007·Current Psychiatry Reports·Mitsuru Toda, Anissa Abi-Dargham
Jan 29, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Joseph C Masdeu
Jan 7, 2004·Journal of Neuroscience Methods·Alexander K ConverseAndrew D Roberts
Dec 4, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Shitij Kapur, David Mamo
Dec 4, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Torgny H Svensson
Jan 16, 2003·Physiology & Behavior·Anthony A Grace, J Amiel Rosenkranz
Sep 23, 2003·Brain Research. Brain Research Reviews·Michael S Lidow
Apr 16, 2003·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·J A González-HernándezP Figueredo-Rodríguez
Oct 3, 2003·Neurobiology of Learning and Memory·Michael E Ragozzino
Jan 29, 2003·Current Opinion in Pharmacology·Michael SpeddingLaszlo Harsing
Apr 12, 2005·Nature Neuroscience·Andreas Meyer-LindenbergKaren F Berman
Aug 21, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Daniel Paul Eisenberg, Karen F Berman
Oct 25, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alexandra SolimanAlain Dagher
Sep 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jean-Claude DreherKaren F Berman
Sep 1, 2009·Proceedings of the National Academy of Sciences of the United States of America·Marta BiagioliStefano Gustincich
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Diana P PrataPhilip McGuire
Jun 6, 2009·Harvard Review of Psychiatry·Joanna Moncrieff
Aug 11, 2007·Brain : a Journal of Neurology·P R CorlettP C Fletcher
Aug 6, 2010·Brain : a Journal of Neurology·Martin VossPatrick Haggard
Mar 28, 2009·Schizophrenia Bulletin·Oliver D Howes, Shitij Kapur
Jun 16, 2009·Schizophrenia Bulletin·Gholson J LyonDavid Sulzer
May 11, 2010·Schizophrenia Bulletin·Andreas Heinz, Florian Schlagenhauf
Oct 27, 2010·Schizophrenia Bulletin·John McGrathDavid St Clair
Jan 28, 2012·Schizophrenia Bulletin·Paolo Fusar-Poli, Andreas Meyer-Lindenberg
Jan 28, 2012·Schizophrenia Bulletin·Paolo Fusar-Poli, Andreas Meyer-Lindenberg
Oct 27, 2010·Pharmacogenetics and Genomics·Anne Emilia Tammimäki, Pekka T Männistö
Dec 2, 2009·Nuclear Medicine Communications·Nora S VyasBasant K Puri
Jan 7, 2010·Current Opinion in Psychiatry·M ZinkAndreas Meyer-Lindenberg
Oct 3, 2007·Genes, Brain, and Behavior·K Scearce-LevieL Mucke
Jun 28, 2012·Acta Neuropsychiatrica·Kai Macdonald, David Feifel
Aug 25, 2007·Annual Review of Clinical Psychology·D M Barch
Aug 20, 2002·Annual Review of Psychology·Terry E Robinson, Kent C Berridge
Feb 10, 2007·The Journal of Clinical Investigation·Andreas Meyer-LindenbergDaniel R Weinberger
Feb 15, 2005·BMC Medical Genetics·Daniel R Hanson, Irving I Gottesman
Jul 19, 2006·Diagnostic Pathology·Shaheen Emmanuel Lakhan
Jan 19, 2008·The British Journal of Psychiatry. Supplement·Oliver D HowesPhilip McGuire
Nov 9, 2006·PLoS Medicine·Jeffrey T-J HuangSabine Bahn
Apr 13, 2011·Journal of Psychiatry & Neuroscience : JPN·Cecilia Flores
May 18, 2006·Psychiatry·Christopher J Hough, Robert J Ursano
May 10, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yong Sang JoSheri J Y Mizumori
Jan 30, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·T W WeickertVenkata S Mattay
Jan 19, 2011·Imaging in Medicine·Judy ThompsonAnissa Abi-Dargham
Jun 13, 2012·The Primary Care Companion to CNS Disorders·Shibu P ThomasSwaran P Singh
Feb 1, 2014·Psychopharmacology·Duncan SinclairCynthia Shannon Weickert
May 28, 2014·Neuroscience Letters·Alanna GrantCecilia Flores
Sep 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jan GrimmArnon Rosenthal
Mar 13, 2014·Schizophrenia Bulletin·Sophia Frangou
Jul 26, 2012·ISRN Pharmacology·Kyra-Verena SendtDerek K Tracy
Jan 1, 2014·European Archives of Psychiatry and Clinical Neuroscience·M R WilliamsM Maier
Jul 19, 2013·Schizophrenia Bulletin·Orwa DandashBen J Harrison
May 9, 2014·Neurotoxicity Research·Trevor ArcherMax Rapp Ricciardi
Mar 29, 2014·Journal of Exercise Rehabilitation·Joon-Ki ParkTae-Won Kim
Feb 8, 2014·Molecular Neurobiology·Shane V HegartyGerard W O'Keeffe
Jul 16, 2014·Molecular Psychiatry·K Brami-CherrierE Borrelli
Nov 13, 2015·Nordic Journal of Psychiatry·Louise K HoeffdingHenrik B Rasmussen
May 4, 2013·Expert Opinion on Investigational Drugs·Naren P Rao, Gary Remington
Apr 28, 2009·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Gerald StoberPeter Riederer
Mar 30, 2013·Journal of Psychiatric Research·Ximena GoldbergLourdes Fañanás
Feb 26, 2005·Annals of Neurology·Dena G HernandezAndrew B Singleton
Jun 15, 2011·Progress in Neurobiology·Viola Oertel-KnöchelHarald Hampel
Apr 13, 2011·Biological Psychiatry·Guillaume BarbalatChlöé Farrer
Oct 20, 2010·Progress in Neurobiology·Alan S Brown
Sep 21, 2010·L'Encéphale·A Del CulP Fossati
Feb 2, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Tejas S BhojrajMatcheri S Keshavan
Jun 30, 2009·Neuroscience and Biobehavioral Reviews·Heike TostAndreas Meyer-Lindenberg
Sep 24, 2015·Molecular Psychiatry·M A Landek-SalgadoA Sawa
Oct 22, 2008·Psychiatry Research·Do-Hyung KangJun Soo Kwon
Nov 15, 2008·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Jaana Markela-LerencStefan Kaiser
May 30, 2008·Pharmacology, Biochemistry, and Behavior·Alberto Del Arco, F Mora
Oct 16, 2007·Schizophrenia Research·Kristen J PrenticeRobert W Buchanan
Jan 1, 2007·PET Clinics·Kimberly P Lindsey, S John Gatley
Oct 2, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·S A Castner, G V Williams
Sep 15, 2007·Neuroscience and Biobehavioral Reviews·Szabolcs Kéri
Dec 5, 2015·Frontiers in Psychiatry·Seong-Wook KimSukchan Lee
Mar 21, 2007·Sleep Medicine·Ellen T Kahn-GreeneWilliam D S Killgore
Mar 14, 2016·Schizophrenia Research·Vilte E BarakauskasWilliam G Honer
Dec 7, 2006·Neuroimaging Clinics of North America·Kimberly P Lindsey, S John Gatley
Nov 3, 2015·Journal of Psychiatric Research·Anja RichterOliver Gruber
Nov 19, 2004·The European Journal of Neuroscience·John G HowlandAnthony G Phillips
Jun 26, 2004·The European Journal of Neuroscience·Mustapha BennayMichael Koch
Nov 20, 2003·Annals of the New York Academy of Sciences·Patricia S Churchland
Dec 20, 2003·Annals of the New York Academy of Sciences·Marc LaruelleAnissa Abi-Dargham
Jun 7, 2013·The European Journal of Neuroscience·Meagan L AugerCecilia Flores
Aug 24, 2013·The European Journal of Neuroscience·Katharina SchmackPhilipp Sterzer
Jan 5, 2011·CNS Neuroscience & Therapeutics·Nobumi MiyakeAnissa Abi-Dargham
Jan 5, 2011·CNS Neuroscience & Therapeutics·Jussi Hirvonen, Jarmo Hietala
Nov 16, 2012·Human Brain Mapping·Liangsuo MaF Gerard Moeller
Oct 3, 2014·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·D M Barch, Julia M Sheffield
Feb 21, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Tineke LatasterJim van Os
Apr 22, 2005·Neuroscience Letters·Izuru MatsumotoBrian Dean
Mar 1, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Daniel Paul EisenbergKaren F Berman
Jan 12, 2005·European Psychiatry : the Journal of the Association of European Psychiatrists·Anissa Abi-Dargham, Marc Laruelle
Jan 18, 2005·Schizophrenia Research·T-U W Woo, A L Crowell
Oct 12, 2004·Trends in Neurosciences·Georg Winterer, Daniel R Weinberger
May 10, 2006·Biological Psychiatry·Hidehiko TakahashiTetsuya Suhara
Aug 25, 2009·Annales d'endocrinologie·S ChabrouxA Penfornis
Sep 6, 2005·NeuroImage·Georg JuckelAndreas Heinz
May 22, 2016·Biological Psychiatry·Jodi J WeinsteinAnissa Abi-Dargham
Mar 18, 2004·Neuroimaging Clinics of North America·David ErritzoeAnissa Abi-Dargham
Aug 12, 2015·Schizophrenia Research·Xiangpeng WangAntao Chen
Jul 11, 2014·Brain Structure & Function·Tobias GleichJürgen Gallinat
May 29, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Maxime CazorlaChristoph Kellendonk
Mar 16, 2012·Biological Psychiatry·Mette Ødegaard NielsenBirte Glenthøj
Apr 23, 2013·Developmental Biology·Shane V HegartyGerard W O'Keeffe
Mar 20, 2012·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Marta PeciñaJon-Kar Zubieta
May 28, 2013·Schizophrenia Research·Meredith A ReidAdrienne C Lahti
Jul 26, 2013·Expert Opinion on Therapeutic Targets·Jenny LamHeike Wulff
Jun 1, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Giampiero MeliLuigi Cataldi
Mar 26, 2015·Psychological Medicine·S C T Peetersfor Genetic Risk and Outcome of Psychosis (G.R.O.U.P.)
Jun 4, 2015·Neuroscience·S S BolkanChristoph Kellendonk
May 27, 2015·Nature Neuroscience·Christoph Kellendonk, Joshua A Gordon
Dec 19, 2006·NeuroImage·Ingo VernalekenGerhard Gründer
Dec 12, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Gagan Fervaha, Gary Remington
Sep 17, 2014·Schizophrenia Research·Jiang Li, Herbert Y Meltzer
Mar 19, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Marco BortolatoMarylou V Solbrig
Aug 22, 2012·The International Journal of Neuropsychopharmacology·Ingo VernalekenGerhard Gründer
Nov 2, 2006·The International Journal of Neuropsychopharmacology·Hans BouwmeesterJan M van Ree
Oct 27, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Mordechai LorberboymRuth Djaldetti
Jun 20, 2016·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Sean James FallonAdrian M Owen
Jun 11, 2016·Neuroscience and Biobehavioral Reviews·Md Shaki MostaidChad A Bousman
Jun 18, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Andrea SchmittWFSBP Task Force on Biological Markers
Jul 21, 2015·PloS One·Mineki OguchiMasamichi Sakagami
Aug 23, 2008·Thérapie·Marie-Pascale Martres
Mar 14, 2007·International Review of Neurobiology·Yukiori Goto, Anthony A Grace
Sep 7, 2016·Schizophrenia Research·Orwa DandashAlex Fornito
Aug 24, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kirsten E SchoonoverRosalinda C Roberts
Sep 23, 2016·PloS One·Ruth de Diego-BalaguerFrench Speaking Huntington Group
Jan 12, 2008·Trends in Pharmacological Sciences·Philip McGuirePaolo Fusar-Poli
Sep 11, 2016·The International Journal of Neuropsychopharmacology·Ana WeidenauerMatthäus Willeit
Dec 6, 2016·Expert Review of Neurotherapeutics·H GeertsPatrick Roberts
May 1, 2016·Trends in Neurosciences·Joseph C MasdeuKaren F Berman
Apr 8, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Daniel Paul EisenbergKaren F Berman
Mar 31, 2017·International Journal of Molecular Sciences·Matea Nikolac PerkovicNela Pivac
Jan 15, 2015·Journal of Psychopharmacology·Oliver D HowesJames Stone
Jul 29, 2008·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Roshan Cools
Sep 10, 2005·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Charles R Yang, Long Chen
Oct 2, 2009·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Yoshitaka Kumakura, Paul Cumming
Sep 5, 2015·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Ajit Ranganath, Simon N Jacob
Nov 19, 2003·The Journal of Comparative Neurology·E Chris MulyYoland Smith
Sep 9, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Andrea GiuffridaDaniele Piomelli
Jan 18, 2017·Translational Psychiatry·Tertia D Purves-TysonCynthia Shannon Weickert
Jun 13, 2018·The Cochrane Database of Systematic Reviews·Hosam E MatarStephanie Sampson
Sep 22, 2006·Nature Reviews. Neuroscience·Andreas Meyer-Lindenberg, Daniel R Weinberger
Nov 21, 2015·The Journal of Nervous and Mental Disease·James A WaltzJames Gold
Jul 28, 2013·CPT: Pharmacometrics & Systems Pharmacology·H GeertsA Spiros
Feb 3, 2018·Schizophrenia Bulletin·Kazuhito NakaoKazu Nakazawa
Oct 13, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Franck SchürhoffMarion Leboyer
Nov 30, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Kambiz N AlavianHorst H Simon
Feb 9, 2019·Psychiatry and Clinical Neurosciences·Tom Macpherson, Takatoshi Hikida
Mar 7, 2018·Translational Psychiatry·Michael J MinzenbergCameron S Carter
Nov 12, 2010·Nature·Andreas Meyer-Lindenberg
Jun 12, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mitsuyuki MatsumotoJoel E Kleinman
Mar 26, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gerhard GründerPaul Cumming
Jan 1, 2015·Nature Reviews. Disease Primers·René S KahnThomas R Insel
Nov 26, 2009·Expert Review of Proteomics·Nicoletta Baloyianni, George Th Tsangaris
Jul 19, 2013·The Cochrane Database of Systematic Reviews·Hosam E MatarStephanie Sampson
Nov 8, 2013·American Journal of Physiology. Cell Physiology·Kalpit ShahNeil A Bradbury
Oct 10, 2019·Psychiatry and Clinical Neurosciences·Daiki SasabayashiMichio Suzuki
Oct 20, 2004·CNS Drug Reviews·Peter SalmiBjörn Kull
Jul 28, 2018·Brain : a Journal of Neurology·Felipe V Gomes, Anthony A Grace
Sep 9, 2020·NPJ Schizophrenia·J N de BoerI E C Sommer
Apr 8, 2011·Expert Review of Neurotherapeutics·Gary RemingtonGeorge Foussias
May 20, 2017·Brain and Behavior·Mascha Van't WoutBenjamin D Greenberg
Oct 9, 2019·Scientific Reports·Eric B EmmonsNandakumar S Narayanan
Jul 29, 2020·Frontiers in Psychiatry·Susan F SonnenscheinAnthony A Grace
Sep 17, 2003·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Rodrigo A Bressan, Lyn S Pilowsky
Jun 3, 2005·Brain : a Journal of Neurology·Michio SuzukiMasayoshi Kurachi
Nov 20, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Euitae KimJun Soo Kwon
Feb 15, 2019·Frontiers in Human Neuroscience·Ariel W Snowden, Catalin V Buhusi
Jul 6, 2019·Psychopharmacology·Trevor W Robbins, Rudolf N Cardinal
Oct 18, 2014·Molecular Medicine Reports·Tae-Woon KimChang-Ju Kim
Nov 3, 2020·Frontiers in Immunology·Tertia D Purves-TysonCynthia Shannon Weickert
Jan 29, 2021·The Journal of Sexual Medicine·Sebastián Vargas-CáceresJ Antoni Ramos-Quiroga

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