Reduced primary antibody responses in a genetic animal model of depression

Psychosomatic Medicine
Elliot FriedmanDavid A Lawrence

Abstract

Clinical depression is associated with multiple abnormalities of immune function, including reduced virus-specific responses. This study tested the hypothesis that the Flinders Sensitive Line (FSL) rat, a promising genetic animal model of depression, would exhibit reductions in antigen-specific primary antibody responses to immunization. FSL (N = 13) and control Flinders Resistant Line (FRL; N = 14) rats were immunized with the protein antigen keyhole limpet hemocyanin (KLH; 300 microg/kg), and KLH-specific immunoglobulin (Ig)M, IgG, IgG1, and IgG2a responses were measured before and 3, 5, 7, 11, and 14 days after immunization. In separate experiments, production of interferon-gamma (IFN-gamma) by cells from naive and KLH-immunized animals was measured in vitro to determine whether strain differences in antibody production might be associated with differential production of this regulatory cytokine. KLH-specific production of IgM (p <.01) and IgG2a (p <.05) was significantly reduced in the FSL rats compared with the FRL controls. There were no strain differences in IgG or IgG1 production. Although IFN-gamma production between the two strains was similar in naive animals, cells from KLH-immunized FSL rats produced significantly ...Continue Reading

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Citations

May 5, 2004·Experimental Physiology·T PriorP K Rangachari
Feb 1, 2003·Biological Psychiatry·David H OverstreetDavid S Janowsky
Jun 1, 2005·Neuroscience and Biobehavioral Reviews·David H OverstreetGal Yadid
Oct 4, 2014·Behavioural Brain Research·Nina StrennAgneta Ekman
Nov 24, 2006·The Spanish Journal of Psychology·Igor P AshmarinElena V Shmalgausen
Aug 16, 2019·Frontiers in Neuroendocrinology·L S KalinichenkoC P Müller

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