Reduced pro-inflammatory profile of γδT cells in pregnant patients with rheumatoid arthritis

Arthritis Research & Therapy
Manuela ThamFrauke Förger

Abstract

During pregnancy, many patients with rheumatoid arthritis (RA) experience disease improvement, whereas patients with ankylosing spondylitis often suffer from persistent active disease. Here we investigated whether pregnancy-related changes in disease activity were associated with changes in the proportion and function of γδT cells. The study population comprised 55 patients with RA, 31 patients with ankylosing spondylitis, and 35 healthy controls. Among these participants, 28 RA patients, 21 ankylosing spondylitis patients, and 23 healthy controls were investigated once before conception when possible, at each trimester of pregnancy, and at 8 weeks postpartum. Data were compared with age-matched non-pregnant patients to obtain disease-related background. In all subjects, peripheral Vδ1 and Vδ2 T cells were analyzed for cell frequencies, the activation marker CD69, the cytotoxicity markers NKG2D and NKG2A, and the intracellular cytokines tumor necrosis factor (TNF)α, interferon (IFN)γ, interleukin (IL)-17 and IL-10. Pregnant patients showed a decreased Vδ2/Vδ1 ratio in the third trimester, which resulted from a slightly reduced proportion of Vδ2 cells. Changes in RA disease activity during pregnancy and postpartum were not assoc...Continue Reading

References

Dec 1, 1990·Scandinavian Journal of Immunology·M D SmithL Mackenzie
Apr 28, 2000·International Immunology·L Mincheva-NilssonV Baranov
Mar 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aliz BarakonyiJulia Szekeres-Bartho
May 30, 2002·Nature Reviews. Immunology·Simon R Carding, Paul J Egan
Sep 27, 2002·American Journal of Reproductive Immunology : AJRI·Olga NagaevaLucia Mincheva-Nilsson
Feb 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karen RoessnerRalph C Budd
Jan 31, 2004·American Journal of Reproductive Immunology : AJRI·Laszlo SzeredayJulia Szekeres-Bartho
Feb 21, 2006·Journal of Reproductive Immunology·Akiko IshitaniKatsuhiko Hatake
Apr 28, 2009·Journal of Reproductive Immunology·Eva MikoJulia Szekeres-Bartho
Jun 23, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Malin HedlundLucia Mincheva-Nilsson
Jun 12, 2010·Nature Reviews. Immunology·Marc BonnevilleWilli K Born
Oct 15, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Mark A Exley, Jonathan E Boyson
Dec 6, 2011·Cellular & Molecular Immunology·Chaoying HuDongqing Zhang
Dec 14, 2011·Autoimmunity Reviews·Monika ØstensenFrauke Förger
Mar 28, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anna BenderskyIlan Bank

❮ Previous
Next ❯

Citations

Feb 11, 2019·Scandinavian Journal of Immunology·Hua MaSonglou Yin
Jan 15, 2020·Nature Reviews. Rheumatology·Frauke Förger, Peter M Villiger
May 26, 2016·The Journal of Clinical Endocrinology and Metabolism·Sijie FangBin Li
Apr 1, 2020·Seminars in Arthritis and Rheumatism·Charles RaineIan Giles

❮ Previous
Next ❯

Methods Mentioned

BETA
Assay
density-gradient centrifugation
PMA
fluorescence-activated cell sorter

Software Mentioned

FlowJo

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.