Reduced proliferation capacity of lung cells in chronic obstructive pulmonary disease

Zeitschrift für Gerontologie und Geriatrie
Babett Bartling, Hans-Stefan Hofmann

Abstract

The prevalence of chronic obstructive pulmonary disease (COPD) and lung emphysema increases with age and both lung diseases are again risk factors for lung cancer. Since a reduced capacity of fibroblasts for proliferation is a good indicator of tissue aging, we studied the cell proliferation of lung fibroblasts from normal and tumor tissue of lung cancer patients depending on lung comorbidities. Fibroblasts were isolated from tumor and normal lung tissue of 40 lung cancer patients. Cumulative population doubling (CPD) was determined to assess the proliferation capacity, and the PCR technique was used to measure telomere lengths. Since many patients had previously been exposed to severe air pollution, we also studied the effect of air pollution particles on the fibroblast CPD in vitro. Fibroblasts from tumor and normal lung tissue had comparable CPDs; however, the CPD of fibroblasts from both tumor and normal lung tissue was significantly reduced in patients also suffering from COPD. This CPD reduction was highest in COPD patients who had already developed emphysema or were smokers. A significant correlation between CPD and telomere length was identified only for fibroblasts of non-COPD patients. Further studies also showed an a...Continue Reading

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Citations

Sep 13, 2019·International Journal of Molecular Sciences·Li ZuoTingyang Zhou
Aug 25, 2020·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Antonino Di StefanoMaria Graziella Catalano
Dec 20, 2018·International Journal of Molecular Sciences·Necola GuerrinaCarolyn J Baglole
Mar 13, 2021·Journal of Food Biochemistry·Sadiya Bi Shaikh, Yashodhar Prabhakar Bhandary

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