Reduced protease inhibitory capacity in patients with abdominal aortic aneurysms is reversed with surgical repair

Journal of Vascular Surgery
Vivienne J HalpernJon R Cohen

Abstract

Abdominal aortic aneurysm (AAA) disease is a complex degenerative process that is associated with elevated proteolytic activity. This increased proteolytic activity may be linked to an imbalance in the protease regulatory mechanisms. We hypothesize that reduced AAA plasma inhibitory capacity is related to increased elastolytic activity observed in patients with AAA, which promotes matrix degradation in the aortic wall and AAA expansion. Preoperative plasma from patients with AAA (n = 86; mean age, 75 +/- 8 years) and healthy controls (n = 30; mean age, 72 +/- 10 years) was assayed for inhibitory capacity. Postoperative plasma inhibitory capacity was evaluated with comparison of the activity of porcine pancreatic elastase on succinylated elastin substrate, in the presence and absence of AAA and control plasma. AAA plasma showed a significantly reduced capacity to inhibit porcine pancreatic elastase (71.31% +/- 1.47%) compared with control plasma (85.52% +/- 1.70%; P <.001). Within the AAA group, the inhibitory capacity increased with AAA diameter (P <.05). In addition, surgical repair of AAA resulted in a significant increase in plasma inhibitory capacity (79.83% +/- 1.86%) as compared with preoperative levels (63.98% +/- 2.69%;...Continue Reading

References

Jan 1, 1991·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·J R CohenL Wise
May 1, 1991·Annals of Vascular Surgery·C M BrophyM D Tilson
May 1, 1987·Atherosclerosis·J S CampaJ T Powell
Aug 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·T FreestoneJ T Powell
Jul 1, 1994·The British Journal of Surgery·S T MacSweeneyR M Greenhalgh
Oct 1, 1994·The Journal of Surgical Research·D J MinionB T Baxter
Aug 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·K M NewmanM D Tilson
Nov 1, 1993·European Journal of Vascular Surgery·N SakalihasanC M Lapière
Jan 1, 1996·Archives of Surgery·A K GregoryM D Tilson
Jul 1, 1996·Journal of Vascular Surgery·N SakalihasanC M Lapière
Nov 18, 1996·Annals of the New York Academy of Sciences·R W Thompson, W C Parks
Aug 1, 1997·Analytical Biochemistry·S K RaoJ R Cohen
Jun 1, 1997·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·J J GrangeB T Baxter
Dec 31, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·J JuvonenT Juvonen
May 20, 1998·Annals of Vascular Surgery·J R ElmoreD J Carey
Oct 9, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·V DavisB T Baxter
Jan 12, 1999·Journal of Vascular Surgery·W D McMillan, W H Pearce
Mar 4, 1999·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·A N ElzoukiS Eriksson
Mar 9, 1999·The Journal of Surgical Research·S K RaoJ R Cohen
Sep 14, 2000·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·J S LindholtL Heickendorff
Jan 13, 2001·Clinical Chemistry and Laboratory Medicine : CCLM·V TreskaL Pecen

❮ Previous
Next ❯

Citations

Mar 3, 2009·Arthritis Research & Therapy·Vaidehi R ChowdharyEric L Matteson
May 27, 2004·The American Journal of Pathology·Vincent FontaineJean-Baptiste Michel
Mar 12, 2004·The Journal of Surgical Research·J Jeffrey Alexander
Jul 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·A I Kakafika, D P Mikhailidis
Aug 30, 2021·Annals of Vascular Surgery·Laura PiniClaudio Tantucci

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.

Aortic Aneurysm

An aortic aneurysm is the weakening and bulging of the blood vessel wall in the aorta. This causes dilatation of the aorta, which is usually asymptomatic but carries the risk of rupture and hemorrhage. Find the latest research on aortic aneurysms here.