Reduced pulmonary clearance of endothelin-1 in pulmonary hypertension

American Heart Journal
J DupuisJ Crépeau

Abstract

Pulmonary hypertension (PHT) is associated with increased endothelin-1 (ET-1) levels that correlate with the severity of the disease. The pulmonary circulation is an important site for ET-1 metabolism and may modulate plasma ET-1 through an increase in production, a reduction in removal, or a combination of both. We measured and compared pulmonary metabolism of circulating ET-1 in controls and in patients with PHT. The indicator-dilution technique was combined with measurements of ET-1 levels to quantify pulmonary metabolism of ET-1 in controls (n = 13) and in patients with PHT (n = 17). ET-1 levels doubled in PHT (p < 0.05) and, although there was no difference between aortic and pulmonary artery levels in controls (0.68+/-0.09 and 0.61+/-0.08 pg/ml, respectively, p = 0.22), they tended to be higher in PHT (1.23+/-0.26 vs 1.07+/-0.19 pg/ml, p = 0.08). Pulmonary extraction of tracer iodine-125-ET-1 was reduced from 47%+/-2.0% in the controls to 34%+/-3.6% in PHT (p = 0.005) and inversely correlated with the severity of pulmonary hypertension (r = -0.524, p = 0.03). Consequently, circulating ET-1 clearance was reduced by PHT from 1424+/-77 ml/min to 892+/-119 ml/min (p < 0.001). Pulmonary production of circulating ET-1 (in picog...Continue Reading

References

Jul 31, 1991·Biochemical and Biophysical Research Communications·A SakamotoT Masaki
Mar 15, 1991·Annals of Internal Medicine·D J StewartD Langleben
Mar 30, 1990·Biochemical and Biophysical Research Communications·M L SirviöF Fyhrquist
Jan 1, 1989·Journal of Cardiovascular Pharmacology·E AnggårdJ R Vane
Jan 1, 1993·Journal of Cardiovascular Pharmacology·R YorikaneK Goto
Apr 17, 1995·Biochemical and Biophysical Research Communications·S OzakiM Yano
Mar 30, 1994·Biochemical and Biophysical Research Communications·T FukurodaM Nishikibe
Jun 17, 1993·The New England Journal of Medicine·A GiaidD J Stewart
Feb 28, 1997·Atherosclerosis·B A Forster, P D Weinberg

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Citations

Nov 2, 2014·Clinical and Translational Imaging : Reviews in Nuclear Medicine and Molecular Imaging·Jocelyn DupuisQuang T Nguyen
Mar 12, 2008·High Altitude Medicine & Biology·Valeriy B ShatiloTatiana V Serebrovskaya
Apr 24, 2010·American Journal of Respiratory and Critical Care Medicine·Roberta L KellerJeffrey R Fineman
Mar 8, 2016·International Journal of Cardiology·Pierpaolo PellicoriJohn G F Cleland
Aug 21, 2015·Expert Opinion on Pharmacotherapy·Swanny PerrinOlivier Sitbon
Jul 1, 2008·Pharmacology & Therapeutics·Daphne MerkusDirk J Duncker
Feb 29, 2008·La Revue de médecine interne·I MarieH Lévesque
Feb 19, 2008·Translational Research : the Journal of Laboratory and Clinical Medicine·Anne CharlouxBernard Geny
Apr 13, 2007·Pulmonary Pharmacology & Therapeutics·Rosario RossiMaria Grazia Modena
Apr 2, 2009·European Journal of Clinical Investigation·S S Pullamsetti, R T Schermuly
Jul 21, 2006·Annals of the New York Academy of Sciences·Gian Paolo Rossi, Gisella Pitter
Aug 12, 2004·Seminars in Arthritis and Rheumatism·Yolanda Braun-MoscoviciAlexandra Balbir-Gurman
Jun 1, 2001·The Journal of Thoracic and Cardiovascular Surgery·P MathieuL C Pelletier
Aug 22, 2006·European Journal of Clinical Investigation·C F Opitz, R Ewert
May 18, 2007·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Takahiro ImaizumiTeruo Takano
Nov 17, 2009·Journal of the American College of Cardiology·Ronald J OudizUNKNOWN ARIES Study Group
May 30, 2009·Journal of cardiology·Yoshimune HiramotoKeiko Yamauchi-Takihara
Nov 26, 2014·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Marie-Camille ChaumaisOlivier Sitbon
May 7, 2014·La Presse médicale·Vincent Richard
Jan 20, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Raymond L BenzaRobyn J Barst
Nov 1, 2005·The Journal of Thoracic and Cardiovascular Surgery·Frank LangerHans-Joachim Schäfers
May 21, 2004·Expert Review of Cardiovascular Therapy·Kelly Chin, Richard Channick
Nov 26, 2003·Anesthesiology·Gilbert BlaiseBernard Hubert
Jun 19, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Masaki OkajimaMichel Lavallée
Oct 2, 2009·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Sohita Dhillon, Gillian M Keating

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