Reduced rate of copy number aberrations in mucinous colorectal carcinoma

Oncotarget
Niek HugenIris D Nagtegaal

Abstract

Mucinous carcinoma (MC) is found in 10%-15% of colorectal cancer (CRC) patients. It differs from the common adenocarcinoma (AC) in histopathological appearance and clinical behavior. Genome-wide DNA copy number and survival data from MC and AC primary CRC samples from patients from two phase III trials (CAIRO and CAIRO2) was compared. Chromosomal copy number data from The Cancer Genome Atlas (TCGA) was used for validation. Altogether, 470 ACs were compared to 57 MCs. MC showed a reduced amount of copy number aberrations (CNAs) compared with AC for the CAIRO/CAIRO2 cohort, with a median amount of CNAs that was 1.5-fold lower (P = 0.002). Data from TCGA also showed a reduced amount of CNAs for MC. MC samples in both cohorts displayed less gain at chromosome 20q and less loss of chromosome 18p. A high rate of chromosomal instability was a strong negative prognostic marker for survival in MC patients from the CAIRO cohorts (hazard ratio 15.60, 95% CI 3.24-75.05). Results from this study indicate that the distinct MC phenotype is accompanied by a different genetic basis when compared with AC and show a strong association between the rate of chromosomal instability and survival in MC patients.

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Citations

Sep 1, 2015·Current Colorectal Cancer Reports·Iris D Nagtegaal, Niek Hugen
Sep 2, 2015·Nature Reviews. Clinical Oncology·Niek HugenIris D Nagtegaal
Dec 20, 2018·BMC Cancer·Vincenza BarresiDaniele F Condorelli
May 6, 2021·Scientific Reports·Bastien NguyenNikolaus Schultz

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Methods Mentioned

BETA
chromosomal aberrations
PCR

Clinical Trials Mentioned

NCT00312000
NCT00208546

Software Mentioned

GeneScan
R package ‘ CGHregions ’
R package ‘ CGHcall ’
BEDTools
LINUX shell
R package ‘ CGHbase ’
nocnv
R
SPSS

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