Reduced rate of knee extensor torque development in older adults with knee osteoarthritis is associated with intrinsic muscle contractile deficits

Experimental Gerontology
Damien M CallahanMichael J Toth

Abstract

We examined the effect of knee osteoarthritis on the rate of torque development (RTD) of the knee extensors in older adults with advanced-stage knee osteoarthritis (OA; n=15) and recreationally-active controls (n=15) of similar age, sex and health status, as well as the relationship between RTD and the size and contractility of single muscle fibers. OA participants had lower RTD when expressed in absolute terms (Nm/ms). There were sex differences in peak RTD (P<0.05), with greater RTD in men, but no group by sex interaction effects for any variables. The lower RTD in OA versus controls was not explained by variation between groups in the fiber type admixture of the muscle, and was mitigated when RTD was normalized to peak torque (PT). In knee OA volunteers, we found strong correlations between the RTD expressed relative to PT and the velocity of contraction of single myosin heavy chain (MHC) I and IIA/X muscle fibers (r=0.652 and 0.862; both P<0.05) and power output of MHC I fibers (r=0.642; P<0.05). In controls, RTD relative to PT was related to fiber cross-sectional area of MHC IIA/X fibers (r=0.707; P<0.05), but not measures of single fiber contractile performance. To our knowledge, these results represent the first demonstr...Continue Reading

Associated Clinical Trials

Aug 27, 2010·Michael J. Toth, Ph.D.

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Citations

Apr 12, 2016·Archives of Physical Medicine and Rehabilitation·Allison M GustavsonJennifer E Stevens-Lapsley
Apr 14, 2018·Journal of Athletic Training·Alexa K JohnsonLindsey K Lepley
Jan 19, 2019·Advances in Rheumatology·Deborah Hebling SpinosoMarcelo Tavella Navega
May 11, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Timothy W TourvilleMichael J Toth
Aug 20, 2021·Scandinavian Journal of Medicine & Science in Sports·Carlos Rodriguez-LopezEvelien Van Roie

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