Reduced red blood cell deformability in Plasmodium knowlesi malaria.

Blood Advances
Bridget E BarberTsin W Yeo

Abstract

The simian parasite Plasmodium knowlesi can cause severe and fatal human malaria. However, little is known about the pathogenesis of this disease. In falciparum malaria, reduced red blood cell deformability (RBC-D) contributes to microvascular obstruction and impaired organ perfusion. In P knowlesi infection, impaired microcirculatory flow has been observed in Macaca mulatta (rhesus macaques), unnatural hosts who develop severe and fatal disease. However, RBC-D has not been measured in human infection or in the natural host M fascicularis (long-tailed macaques). Using ektacytometry, we measured RBC-D in adults with severe and non-severe knowlesi and falciparum malaria and in healthy controls. In addition, we used micropipette aspiration to determine the relative stiffness of infected RBCs (iRBCs) and uninfected RBCs (uRBCs) in P knowlesi-infected humans and M fascicularis Ektacytometry demonstrated that RBC-D overall was reduced in human knowlesi malaria in proportion to disease severity, and in severe knowlesi malaria, it was comparable to that of severe falciparum malaria. RBC-D correlated inversely with parasitemia and lactate in knowlesi malaria and HRP2 in falciparum malaria, and it correlated with hemoglobin nadir in know...Continue Reading

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Citations

Jun 7, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Matthew J GriggNicholas M Anstey
Feb 11, 2020·Frontiers in Physiology·Mallorie DepondPapa Alioune Ndour
Oct 21, 2018·Malaria Journal·Nicholas J White
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Mar 20, 2021·Frontiers in Cellular and Infection Microbiology·Damilola R OresegunJanet Cox-Singh
Jan 1, 2022·Malaria Journal·Mariko S PetersonMary R Galinski

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