Reduced reproductive performance in androgen-resistant Tfm/Tfm female mice

Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character
M F Lyon, P H Glenister

Abstract

Androgen-resistant female mice (Tfm/Tfm) homozygous for the mutant gene Tfm were bred by making use of males chimaeric for the Tfm gene. All seven Tfm/Tfm females found were fertile, confirming that a normal level of androgen receptor protein is not essential for reproduction in female mice. However, when five of the seven were studied throughout their reproductive life they proved to have impaired reproductive performance and premature cessation of reproduction. No impairment of reproduction was seen in heterozygous Tfm/+ females. The ovarian histology suggested that in Tfm/Tfm the normal ageing processes were accelerated. This work is consistent with the work of others in that androgen is involved in the control of follicular maturation and atresia, and that the effect is mediated by the androgen receptor coded by the Tfm locus.

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Citations

Jun 5, 2002·Molecular and Cellular Endocrinology·Ann E DrummondJock K Findlay
Feb 27, 2003·Annals of Epidemiology·Laura Torres-ArreolaLizbeth López-Carrillo
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D B LubahnO Smithies
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May 1, 2021·Burns and Trauma·Huaikai ShiYiwei Wang
Apr 20, 2021·Journal of the Endocrine Society·Olga AstapovaStephen R Hammes

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