Reduced resting-state functional connectivity and sleep impairment in abstinent male alcohol-dependent patients

Human Brain Mapping
Jingjing LiuKai Yuan

Abstract

Alcohol dependence is associated with poor sleep quality, which has both been implicated with thalamocortical circuits function. To identify the possible roles of these circuits in the alcohol-sleep association, we investigated the volume of both left and right thalamus and corresponding resting-state functional connectivity (RSFC) differences between 15 alcohol-dependent patients (AD) and 15 healthy controls (HC) male participants. The neuroimaging findings were then correlated with clinical variables, that is, Alcohol Use Disorders Identification Test (AUDIT) and Pittsburgh Sleep Quality Index (PSQI). Additionally, mediation analysis was carried out to test whether the thalamocortical RSFC mediates the relationship between drinking behavior and sleep impairments in AD when applicable. We observed a significant positive correlation between AUDIT score and PSQI score in AD. Compared with HC, AD showed reduced RSFC between the left thalamus and medial prefrontal cortex (mPFC), orbitofrontal cortex, anterior cingulate cortex (ACC), and right caudate. We also observed a negative correlation between RSFC of the left thalamus-mPFC and PSQI score in AD. More importantly, the left thalamus-mPFC RSFC strength mediated the relationship ...Continue Reading

References

Nov 1, 1971·Psychosomatics·W W Zung
Jun 1, 1982·Journal of Abnormal Psychology·H A Skinner, B A Allen
Nov 1, 1995·Journal of Clinical Psychology·J H PattonE S Barratt
Aug 8, 2001·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·S Haber, N R McFarland
Jan 1, 1965·Archives of General Psychiatry·W W ZUNG
Jan 12, 2005·Behavior Research Methods, Instruments, & Computers : a Journal of the Psychonomic Society, Inc·Kristopher J Preacher, Andrew F Hayes
Aug 17, 2005·Pharmacology & Therapeutics·P M Newton, R O Messing
Jun 17, 2006·Science·Randy M Bruno, Bert Sakmann
Oct 19, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sandra ChanraudJean-Luc Martinot
Mar 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David ElmenhorstAndreas Bauer
Aug 22, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nora D VolkowMillard Jayne
Oct 28, 2008·Brain Research Bulletin·Suzanne N Haber, Roberta Calzavara
Mar 13, 2010·Neuroscience and Biobehavioral Reviews·Jodie FeilJohn L Bradshaw
Aug 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·Hedy KoberKevin N Ochsner
Mar 23, 2012·Sleep Medicine·Alessandra Del FelicePaolo Manganotti
Apr 5, 2012·Alcoholism, Clinical and Experimental Research·Nataliya ZhabenkoKirk J Brower
May 11, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nora D VolkowSergi Ferré
Jul 20, 2012·Physiological Reviews·Ritchie E BrownRobert W McCarley
Jul 31, 2012·Appetite·Jean-Philippe ChaputAngelo Tremblay
Aug 4, 2012·Biological Psychiatry·Lianne SchmaalAnna E Goudriaan
Sep 15, 2012·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Timothy Roehrs, Thomas Roth
May 15, 2013·The Journal of Pain : Official Journal of the American Pain Society·Kai YuanJie Tian
Apr 22, 2014·Current Biology : CB·José de Bourbon-TelesDavid Soto
Aug 12, 2014·Neuroscience and Biobehavioral Reviews·Anne Lise PitelHélène Beaunieux
Aug 19, 2014·Pathologie-biologie·J N O'ByrneT T Dang-Vu
Dec 17, 2014·Alcohol·Mahesh M ThakkarPradeep Sahota
May 29, 2015·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Emily E HartwellLara A Ray
Jan 9, 2016·Trends in Neurosciences·Jessica M PhillipsYuri B Saalmann
Feb 18, 2016·Sleep Medicine Reviews·Lukas KroneChristoph Nissen
Mar 30, 2016·Nature Neuroscience·S Murray Sherman
May 12, 2016·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Jessica R DietchBrandy M Roane
Jul 1, 2016·Proceedings of the National Academy of Sciences of the United States of America·Anders EklundHans Knutsson
Oct 21, 2016·Alcoholism, Clinical and Experimental Research·Subhajit ChakravortyKirk J Brower

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SPSS
FMRIB Software Library
FreeSurfer
AUDIT

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