Reduced Retinal Function in the Absence of Na(v)1.6.

PloS One
Benjamin J Smith, Patrice D Côté

Abstract

Mice with a function-blocking mutation in the Scn8a gene that encodes Na(v)1.6, a voltage-gated sodium channel (VGSC) isoform normally found in several types of retinal neurons, have previously been found to display a profoundly abnormal dark adapted flash electroretinogram. However the retinal function of these mice in light adapted conditions has not been studied. In the present report we reveal that during light adaptation these animals are shown to have electroretinograms with significant decreases in the amplitude of the a- and b-waves. The percent decrease in the a- and b-waves substantially exceeds the acute effect of VGSC block by tetrodotoxin in control littermates. Intravitreal injection of CoCl(2) or CNQX to isolate the a-wave contributions of the photoreceptors in littermates revealed that at high background luminance the cone-isolated component of the a-wave is of the same amplitude as the a-wave of mutants. Our results indicate that Scn8a mutant mice have reduced function in both rod and the cone retinal pathways. The extent of the reduction in the cone pathway, as quantified using the ERG b-wave, exceeds the reduction seen in control littermates after application of TTX, suggesting that a defect in cone photorece...Continue Reading

References

Nov 9, 2000·Journal of Neurophysiology·Z H Pan, H J Hu
Feb 4, 2003·The Journal of Physiology·John G RobsonLaura J Frishman
Oct 28, 2003·The Journal of Physiology·Bang V Bui, Brad Fortune
Feb 18, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tomomi IchinosePeter D Lukasiewicz
May 20, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Patrice D CôtéRashmi Kothary
Dec 8, 2005·Visual Neuroscience·Sumit SharmaNeal S Peachey
Jul 11, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Audra Van Wart, Gary Matthews
Sep 26, 2006·Photochemistry and Photobiology·Mahito OhkumaEi-Ichi Miyachi
Apr 27, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tomomi Ichinose, Peter D Lukasiewicz
Apr 5, 2008·The Journal of Physiology·Deb Kumar MojumderLaura J Frishman
Apr 29, 2008·Experimental Eye Research·Suguru ShiratoLaura J Frishman
Jul 5, 2008·Molecular and Cellular Neurosciences·Yuan ChenWilliam A Catterall
Nov 11, 2008·Experimental Eye Research·Yukihide KurimotoHiroko Terasaki
Dec 20, 2008·Visual Neuroscience·Jinjuan Cui, Zhuo-Hua Pan
Mar 3, 2009·Experimental Eye Research·Gen MiuraLaura J Frishman
Oct 15, 2009·The Journal of Comparative Neurology·Lars C HolzhausenSusan E Brockerhoff
Jul 22, 2010·Nature Reviews. Neuroscience·Anand SwaroopDouglas Forrest
Apr 6, 2011·Documenta Ophthalmologica. Advances in Ophthalmology·Trung M DangBang V Bui

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Citations

Mar 25, 2014·Documenta Ophthalmologica. Advances in Ophthalmology·Benjamin J SmithFrançois Tremblay
Aug 27, 2014·Chronobiology International·Benjamin J SmithFrançois Tremblay
Aug 15, 2013·Scientific Reports·Vishnu Priyanka Reddy ChichiliJ Sivaraman

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