Reduced risk of bone metastasis for patients with breast cancer who use COX-2 inhibitors

Clinical Breast Cancer
Matias E ValsecchiWilliam Tester

Abstract

We hypothesize that the use of cyclooxygenase (COX)-2 inhibitors in early disease phases could protect against the development of bony metastases. The medical charts of patients with stage II-III breast cancer diagnosed between 1999 and 2005 were reviewed. Patients were subdivided according to the use of COX-2 inhibitors after the diagnosis and for > or = 6 months. Bivariate analyses were undertaken, and statistically significant variables were included in a multivariate logistic regression model. Eleven percent of patients (74 of 644) who did not use COX-2 inhibitors developed bone metastases compared with 2% (1 of 48) of those who did use COX-2 inhibitors (Fisher exact test, P = .05). Significant predictors for bone metastases in a multivariate logistic regression model included: > or = 3 positive nodes (odds ratio [OR], 3.26 [95% CI, 1.79-5.93]; P < .001), stage IIB-IIIC disease (OR, 3.89 [95% CI: 1.74-8.69]; P = .001) and use of COX-2 inhibitors (OR, 0.12 [95% CI, 0.02-0.88]; P = .037). Adjusting for TNM stage, of the 327 patients with stages IIB-IIIC disease, 22% (63 of 293) had bone metastases in the non-COX-2 group versus 3% (1 of 34) in the COX-2 inhibitors consumers (Fisher exact test, P = .006). In this high-risk grou...Continue Reading

References

Aug 6, 1998·The New England Journal of Medicine·I J DielG Bastert
Aug 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S Eva SingletaryFrederick L Greene
Feb 3, 2005·The Journal of Clinical Endocrinology and Metabolism·Edgar S Díaz-CruzRobert W Brueggemeier
Feb 17, 2005·The New England Journal of Medicine·Scott D SolomonUNKNOWN Adenoma Prevention with Celecoxib (APC) Study Investigators
Dec 3, 2005·Breast Cancer Research and Treatment·Vilmar Marques OliveiraMaria Antonieta Longo Galvão Silva
Jul 11, 2006·Breast Cancer Research and Treatment·Cindy K BlairAaron R Folsom
Jan 11, 2007·Oncogene·B SinghA Lucci
Mar 3, 2007·International Journal of Cancer. Journal International Du Cancer·Lisa GallicchioKathy J Helzlsouer
Apr 4, 2007·Cancer Causes & Control : CCC·Marilyn L KwanBette Caan
Jul 31, 2007·American Journal of Epidemiology·Victoria A KirshBeth Theis
Aug 4, 2007·Breast Cancer Research and Treatment·Ann ReadyEmily White
Aug 19, 2007·American Journal of Epidemiology·Jasmeet K GillLaurence N Kolonel
Jan 16, 2008·International Journal of Clinical Practice·A Agrawal, I S Fentiman

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Citations

Oct 18, 2011·Cancer Metastasis Reviews·Jocelyn ReaderAmy Fulton
Apr 28, 2010·Pharmaceutical Research·Sanjeev BanerjeeRamzi M Mohammad
May 23, 2012·Oncogene·M K HerroonI Podgorski
Jul 4, 2012·Antioxidants & Redox Signaling·Samar BasuMarie-Paule Vasson
Feb 13, 2014·Journal of Enzyme Inhibition and Medicinal Chemistry·Shigeo HayashiJunji Takada
Sep 23, 2011·Cancer Investigation·Young Kwang ChaeWilliam Tester
Oct 7, 2015·Current Pharmacology Reports·Laura W Bowers, Linda A deGraffenried
Jun 10, 2011·Cancer Letters·Hai-yun ShiShu-tian Zhang
May 14, 2017·Scientific Reports·Xiaoping ZhaoHaoseng Li
Aug 17, 2011·Journal of Pathology Informatics·Yahui PengXiming J Yang
Dec 12, 2012·Journal of Carcinogenesis·Takeo ShimasakiToshinari Minamoto
Oct 11, 2019·Future Cardiology·Farouk MookadamMuhammad Shahzeb Khan
Apr 11, 2019·International Journal of Preventive Medicine·Vahid AhmadipanahmehrabadiBehzad Mahaki
Jun 3, 2021·International Journal of Molecular Sciences·Andy GöbelTilman D Rachner
Aug 13, 2010·Current Opinion in Supportive and Palliative Care

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