PMID: 3767265Mar 1, 1986Paper

Reduced serum carnosinase activity in hypothyroidism

Annals of Clinical Biochemistry
K BandoK Miyai

Abstract

Carnosinase hydrolyses carnosine in muscle, and its deficiency is associated with extensive neuromuscular abnormalities. We measured serum carnosinase activity in patients with thyroid dysfunction which often involves neuromuscular systems. In hyperthyroidism, the carnosinase activity was not significantly different from that in normal subjects. In hypothyroidism, however, it was significantly lower than that in normal subjects. The activity examined in five patients with hypothyroidism returned to normal after replacement therapy. In hypothyroidism, the carnosinase activity showed significant correlation with concentration of serum thyroxine and negative correlation with serum creatine kinase activity. This finding may be of practical importance in the differential diagnosis of disorders causing carnosinase deficiency.

Citations

Jul 15, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·A P OrfanosD C Jinks
Oct 14, 2017·Journal of Inherited Metabolic Disease·Verena PetersClaus P Schmitt
Oct 19, 2013·Physiological Reviews·Alexander A BoldyrevWim Derave

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