Reduced serum haptoglobin values in hemophiliacs receiving monoclonally purified factor VIII concentrates

American Journal of Hematology
G R BuchananA Johnson

Abstract

Hemophiliacs often have mild anemia, and hemolysis has been suggested as the likely mechanism on the basis of the reduced serum haptoglobin values frequently observed in these patients. It has been suggested that hypohaptoglobinemia results from isohemagglutinins or other contaminating proteins in the infused factor concentrates. The advent and increased utilization of Factor VIII concentrates that are highly purified by use of monoclonal antibodies have provided the opportunity to study whether proteins other than Factor VIII contained in the concentrate induce hemolysis. Of 49 consecutively studied Factor VIII-deficient hemophiliacs, 19 (39%) had a reduced serum haptoglobin level (less than 27 mg/dl). In particular, 16 of 35 (46%) of patients receiving only monoclonally purified Factor VIII products (Monoclate or Hemofil-M) had a reduced serum haptoglobin value. Haptoglobin measurements were variable on repeat measurement in 8 patients. Haptoglobin levels did not correlate with type or severity of hemophilia, hemoglobin value, or alterations in liver function. Low serum haptoglobin values were also observed in children with leukemia, without apparent hemolysis, who had extensive cutaneous hemorrhage associated with thrombocyt...Continue Reading

References

Jul 1, 1976·The Journal of Pediatrics·R A SeelerJ B Ashenhurst
Feb 1, 1976·The Journal of Pediatrics·J B AshenhurstM C Telfer
Oct 1, 1988·Lancet·P M Mannucci, M Colombo

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Citations

Apr 5, 2012·Journal of Thrombosis and Haemostasis : JTH·Y RepesséS Lacroix-Desmazes
Jul 22, 2014·The Journal of Small Animal Practice·M KocaturkJ J Ceron
Mar 2, 2006·European Journal of Clinical Investigation·G F KörmöcziS Panzer

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