Reduced serum insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 levels in adults with inflammatory bowel disease

Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society
K H KatsanosE V Tsianos

Abstract

In the present study, the changes in circulating IGF-1 and its binding protein IGFBP-3 were determined in adult patients with active inflammatory bowel disease (IBD) in order to assess the effect of this inflammatory condition on the IGF system. IGF-1 and IGFBP-3, as well as interleukin-6 (IL-6) were measured in serum obtained from 22 consecutive newly diagnosed patients (mean age 41.3 years) with active IBD, including 10 patients with Crohn's disease (CD), and 12 with ulcerative colitis (UC). For comparison the same parameters were determined in 30 healthy volunteers matched for age, sex and Body Mass Index (BMI). Serum IGF-1 and IGFBP-3 levels were similar in the two subgroups of patients and the values from all patients were combined for comparison with those from the control group. The mean (+/- SD) serum IGF-1 concentration (178 +/- 91 ng/ml) in the patients with IBD was lower compared with that in the controls (227 +/- 79 ng/ml, P<0.035). Similarly, the mean IGFBP-3 concentration in the patients was lower than in the controls (1.6 +/- 0.6 ng/ml vs 3.2 +/- 0.7 ng/ml respectively, P<0.001), Serum IL-6 levels were higher in the patients compared with the controls (5.5 +/- 4.2 vs 0.65 +/- 0.11 pg/ml, P<0.0001). The reduced IG...Continue Reading

References

Jan 9, 1982·British Medical Journal·S K ChongJ A Walker-Smith
Mar 20, 1999·Baillière's Clinical Endocrinology and Metabolism·R C Jenkins, R J Ross
Jun 22, 1999·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·A TsatsoulisK Seferiadis
Aug 3, 1999·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·G Van den Berghe

❮ Previous
Next ❯

Citations

Aug 5, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Heath D SchmidtRonald S Duman
Jan 21, 2006·Human Heredity·Iuliana Ionita, Shaw-Hwa Lo
Aug 2, 2012·World Journal of Gastroenterology : WJG·Silvia SpecaGiovanni Latella
Jan 1, 2014·World Journal of Gastroenterology : WJG·Gupse AdaliIlyas Tuncer
Nov 2, 2014·BMC Medical Genomics·Swarnalatha Y ReddyWendy A Henderson
Oct 23, 2012·Clinical Genitourinary Cancer·Mehmet Asim BilenShi-Ming Tu
Jan 14, 2009·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Laura A ColangeloSusan M Gapstur
Nov 28, 2006·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Martin EivindsonJens Frederik Dahlerup
Apr 28, 2005·Alimentary Pharmacology & Therapeutics·U Vespasiani GentilucciM Cicala
Oct 18, 2003·The American Journal of Medicine·Luigi Ferrucci, Jack M Guralnik
May 17, 2005·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·J-M ReimundB Duclos
Dec 24, 2014·The American Journal of Tropical Medicine and Hygiene·Andrew D JonesAndrew J Prendergast
Sep 28, 2017·International Journal of Molecular Sciences·Christoffer SoendergaardThomas Lindebo Holm
May 2, 2009·Inflammatory Bowel Diseases·Efstratios AlexandridisGeorgios Kouklakis
Jun 5, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·John F KuemmerleJennifer G Bowers
Aug 2, 2007·Diseases of the Colon and Rectum·A BelizonR L Whelan
Apr 23, 2005·Digestive Diseases and Sciences·Irena KirmanOle Haagen Nielsen
Nov 2, 2006·The Journal of Clinical Endocrinology and Metabolism·Craig ParkinsonPeter J Trainer
Nov 1, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Corinne E MetzgerSusan A Bloomfield
Sep 18, 2003·American Journal of Physiology. Endocrinology and Metabolism·Teresa PriegoAsunción López-Calderón
Mar 21, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Laura HarrisLaura R McCabe
Mar 25, 2018·Journal of Korean Medical Science·Soon Chul Kim, Pyoung Han Hwang
May 10, 2017·International Journal of Molecular Sciences·Christoffer SoendergaardJohn J Kopchick
Oct 19, 2020·Advances in Nutrition·Michał SienkiewiczJakub Fichna
Mar 27, 2021·Current Opinion in Gastroenterology·M S IsmailDeirdre McNamara
Apr 6, 2021·American Journal of Ophthalmology Case Reports·Myra B Safo, Rona Z Silkiss
Aug 14, 2003·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Anders Juul
Mar 13, 2021·Ophthalmic Plastic and Reconstructive Surgery·Davin C AshrafRobert C Kersten

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.