PMID: 9555820Apr 29, 1998Paper

Reduced skin irritation with tretinoin containing polyolprepolymer-2, a new topical tretinoin delivery system: a summary of preclinical and clinical investigations

Journal of the American Academy of Dermatology
J W Quigley, D A Bucks

Abstract

Novel tretinoin cream and gel formulations have been developed that incorporate polyolprepolymer-2, which is a material designed to help retain drug molecules in and on the skin when applied in topical vehicles. The results of preclinical and clinical investigations have confirmed the beneficial impact of such a vehicle on tretinoin tolerability. In vitro studies with selected polyolprepolymer-containing formulations have reduced initial and cumulative tretinoin percutaneous penetration, and guinea pig studies showed that the gel formulation containing polyolprepolymer-2 caused less erythema and edema than did the corresponding commercially-available tretinoin gel formulation. Human studies with tretinoin containing polyolprepolymer-2 have consistently demonstrated a favorable tolerability profile when compared with commercially-available tretinoin. Use of the polyolprepolymer-2-containing tretinoin formulation in human studies has resulted in reductions in peeling--a problem commonly associated with use of standard tretinoin formulations. These reductions in irritation have not been at the expense of efficacy; acne clinical trial results indicate comparable effectiveness between tretinoin containing polyolprepolymer2 and comme...Continue Reading

References

Oct 1, 1986·Journal of the American Academy of Dermatology·J J Leyden, A R Shalita
Oct 31, 1997·Journal of Pharmaceutical Sciences·M J SkovD A Bucks

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Citations

Jun 10, 2000·The British Journal of Dermatology·W J CunliffeG I Stables
Nov 24, 2004·Clinics in Dermatology·Andrea Krautheim, Harald P M Gollnick
Mar 29, 2014·The British Journal of Dermatology·H PomerantzUNKNOWN Veterans Affairs Topical Tretinoin Chemoprevention (VATTC) Group
Oct 12, 2001·Seminars in Cutaneous Medicine and Surgery·S Bershad
May 16, 2008·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Anja ThielitzHarald Gollnick
Nov 1, 2008·American Journal of Clinical Dermatology·Anja Thielitz, Harald Gollnick
May 14, 2011·Postgraduate Medicine·Peter HsuRobert T Brodell
Jun 21, 2007·Journal of Microencapsulation·Gisele A CastroLucas A M Ferreira
Mar 23, 2000·Postgraduate Medicine·B A Johnson, J R Nunley

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