Reduced sleep quality and depression associate with decreased quality of life in patients with pituitary adenomas

European Journal of Endocrinology
Sarah M LeistnerCaroline Sievers

Abstract

Several studies reported decreased quality of life (QoL) and sleep as well as increased rates of depression for patients with pituitary adenomas. Our aim was to explore to what extent differences in depression and sleep quality contribute to differences in QoL between patients with pituitary adenomas and controls. A cross-sectional case-control study. Endocrine Outpatient Unit of the Max Planck Institute of Psychiatry, Munich, Department of Internal Medicine, Ludwig-Maximilians-University, Munich, and the Institute of Clinical Psychology and Psychotherapy, Technical University, Dresden. Patients with pituitary adenomas (n=247) and controls (from the DETECT cohort, a large epidemiological study in primary care patients) matched individually by age and gender (n=757). Sleep quality was assessed with the Pittsburgh Sleep Quality Index (PSQI) and QoL was measured by the generic EQ-5D and calculated by the time trade-off- and VAS-method. Depression was categorized as 'no depression', 'subclinical depression', and 'clinical depression' according to the Beck Depressions Inventory for patients and the Depression Screening Questionnaire for control subjects. General linear and generalized, logistic mixed models as well as proportional o...Continue Reading

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Citations

Mar 30, 2017·European Journal of Endocrinology·Susan M WebbElena Valassi
May 10, 2017·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Xianxiang WangZhongwu Sun
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Apr 13, 2018·Pituitary·Lia Silvia KunzlerLuiz Augusto Casulari
Nov 17, 2020·Frontiers in Human Neuroscience·Fabiola SilvaggiSilvia Schiavolin
Jan 3, 2021·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Megan S JeonHaryana M Dhillon

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