PMID: 6107862Nov 20, 1980Paper

Reduced somatostatin-like immunoreactivity in cerebral cortex from cases of Alzheimer disease and Alzheimer senile dementa

Nature
P DaviesR D Terry

Abstract

Both Alzheimer's disease and senile dementia of the Alzheimer type (AD/SDAT) are progressive dementias characterized neuropathologically by the presence in the cerebral cortex of numerous neurofibrillary tangles and neuritic plaques. We use the abbreviation AD/SDAT to denote all such cases, irrespective of age of onset. Studies of neurotransmitter-related parameters in autopsied brain tissues from patients with AD/SDAT have, to date, been confined to five putative transmitter systems. Acetycholine-releasing neurones seem to be most markedly and consistently affected, as judged by the extensive reductions in choline acetyltransferase (ChAT) and acetylcholinesterase activities that have been reported. Despite numerous studies, there is no consistent evidence for the involvement of neurones releasing dopamine, noradrenaline, serotonin, or gamma-aminobutyric acid in AD/SDAT, nor for loss of muscarinic cholinergic receptors. Thus, the involvement of cholinergic neurones in AD/SDAT seems to be specific. However, the possible involvement of neurones using other chemicals as transmitters has yet to be explored. The recent recognition of the existence of so-called 'peptidergic neurones' in the mammalian brain (for review see ref. 8) and...Continue Reading

References

Mar 26, 1977·Lancet·P WhiteD M Bowen
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Citations

Oct 1, 1991·Annals of Neurology·M M MouradianT N Chase
Dec 1, 1990·Journal of Neuroscience Research·C G Gottfries
Dec 1, 1990·Journal of Neuroscience Research·K J ReinikainenP J Riekkinen
Nov 1, 1992·Journal of Neurobiology·D L PriceL C Cork
Dec 1, 1992·Cellular and Molecular Neurobiology·A J Nazarali, G P Reynolds
Jun 1, 1992·Neuropsychology Review·G A Carlesimo, M Oscar-Berman
Aug 12, 1998·Journal of Molecular Neuroscience : MN·P CorsiJ T Coyle
Jan 1, 1992·Journal of Molecular Neuroscience : MN·C A MarottaB Tate
May 1, 1993·Molecular and Chemical Neuropathology·J HamM F Scanlon
Jun 1, 1990·Aging : Clinical and Experimental Research·M PomponiM Brufani
Jun 1, 1991·Biological Psychiatry·S E MolchanT Sunderland
Jul 8, 1985·Brain Research·D M ArmstrongR D Terry
Jun 24, 1985·Brain Research·J M AllenS R Bloom
May 22, 1981·European Journal of Pharmacology·L Tapia-ArancibiaC Kordon
Sep 1, 1988·European Journal of Pharmacology·S E FreemanM Szilagyi
Mar 29, 1989·European Journal of Pharmacology·M McKinney, R W Barrett

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