PMID: 8445224Jan 1, 1993Paper

Reduced splanchnic vasoconstriction to angiotensin II in conscious rats with biliary cirrhosis

Journal of Hepatology
A BraillonD Lebrec

Abstract

Decreased pressor reactivity to angiotensin II has been demonstrated in portal hypertension due to cirrhosis. The present study investigated the respective roles of portal hypertension and cirrhosis and the hemodynamic mechanisms of the depressor response in different models of portal hypertension in conscious rats. Dose-pressor curves were studied in sham-operated, portal vein stenosed (portal hypertension without cirrhosis) and biliary cirrhotic rats following angiotensin II administration. Decreased pressor response was observed in cirrhotic rats but not in portal vein stenosed rats. The hemodynamic effects of angiotensin II administration (11 ng.100 g-1 body wt.min-1, i.v.) were studied in conscious sham-operated and biliary cirrhotic rats (radioactive microsphere method). The percentage of change from basal values following angiotensin II administration were significantly more marked in sham-operated rats than in cirrhotic rats for mean arterial pressure (+34 vs. +6%), cardiac index (-36 vs. -22%), systemic vascular resistance (+117 vs. +40%). After angiotensin II, portal tributary and hepatic artery blood flows significantly decreased in sham-operated rats (-31 and -14%, respectively) but not in cirrhotic rats (+1 and +23...Continue Reading

References

Dec 1, 1989·Canadian Journal of Physiology and Pharmacology·L M VillamedianaJ M López-Novoa
Oct 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D RoulotD Lebrec
Aug 1, 1985·Archives of Internal Medicine·I A Reid
Jan 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C CarameloL Hernando
Mar 1, 1958·The American Journal of Medicine·J F MURRAYS SHERLOCK

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Citations

Jun 3, 2006·Journal of Gastroenterology·Han-Chieh LinShou-Dong Lee
Jan 1, 1997·Pharmacology & Therapeutics·P W Hadoke, P C Hayes
May 1, 1996·British Journal of Pharmacology·V RalevicG Burnstock
Jan 1, 1997·Journal of Hepatology·J Reichen
Apr 9, 2005·World Journal of Gastroenterology : WJG·Han-Chieh LinShou-Dong Lee
Dec 6, 2007·Journal of Clinical Gastroenterology·Reiner Wiest

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