Reduced stereoacuity in Williams syndrome

American Journal of Medical Genetics
L S SadlerJ D Reynolds

Abstract

Strabismus is a frequently recognized manifestation of Williams syndrome [Greenberg and Lewis, 1988: Ophthalmology 95:1608-1612; Kapp et al., 1995: Am J Ophthalmol 119:355-360]. We recently evaluated the ophthalmologic function of 12 patients with Williams syndrome (WS), with an emphasis on binocularity. Four of 12 patients (33%) had measurable strabismus. Of the 8 remaining patients, examination of binocular function was possible in 6, all of whom demonstrated reduced stereoacuity. We speculate that subnormal binocular vision and the poor visuospatial performance observed in patients with WS may be related to abnormal brain morphogenesis in the region of the occipitoparietal cortex.

References

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Jan 1, 1984·Annual Review of Neuroscience·G F Poggio, T Poggio
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Feb 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·B Gulyás, P E Roland

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Citations

Nov 10, 2001·Annual Review of Genomics and Human Genetics·C A Morris, C B Mervis
Sep 19, 2003·Neurologic Clinics·Mark Nawrot
Dec 12, 2012·Gait & Posture·Stefania BarozziDaniele Brambilla
Apr 18, 2001·Journal of Child Neurology·P KaplanU Francke
Jun 21, 2005·Experimental Brain Research·J N Van der GeestM A Frens
Jun 9, 2006·Nature Reviews. Neuroscience·Andreas Meyer-LindenbergKaren Faith Berman
Nov 12, 2010·Ophthalmic Genetics·Loic PinsardJoseph Colin

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