Reduced striatal dopamine release during motor skill acquisition in Parkinson's disease

PloS One
Shoji KawashimaNoriyuki Matsukawa

Abstract

Striatal dopamine is functionally important for the acquisition of motor skills. However, it remains controversial as to whether intrinsic processing of motor learning is impaired in patients with Parkinson's disease (PD), and if yes, whether the impairment is associated with altered striatal dopamine release. Additionally, most neuro-imaging studies of patients with PD have focused on motor sequence learning. In contrast, skill acquisition, specifically, the reconstruction of muscle control of isolated movements, has barely been studied. In this study, we used a repetitive skill training task to measure the peak acceleration of left thumb movement during a process to achieve fine tuning of motor skill. Using 11C-raclopride (RAC) positron emission tomography, we investigated changes in striatal dopamine levels in two conditions of a skill acquisition task: initial skill training (Day 1) and acquired condition (Day 2) with eight patients with PD and age-matched healthy subjects (HS). In HS, the mean acceleration of each session improved through repeated training sessions on Day 1. However, in patients with PD, the training-associated increase was less than that for HS, and this suggests that repetitive skill training does not re...Continue Reading

References

Oct 1, 1992·Brain : a Journal of Neurology·R AgostinoM Manfredi
Jul 1, 1990·Trends in Neurosciences·M R DeLong
Jun 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·C D FrithK N Carpenter
May 1, 1967·Neurology·M M Hoehn, M D Yahr
May 1, 1994·Movement Disorders : Official Journal of the Movement Disorder Society·R AgostinoM Manfredi
Sep 16, 1993·Nature·A Karni, D Sagi
Sep 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J LoganD L Alexoff
Aug 1, 1996·Journal of the Neurological Sciences·R AgostinoM Hallett
Oct 1, 1995·Journal of Neurophysiology·O HikosakaK Miyashita
Jan 1, 1997·Movement Disorders : Official Journal of the Movement Disorder Society·A AntoniniK L Leenders
Dec 1, 1996·Brain : a Journal of Neurology·P K MorrishD J Brooks
Aug 1, 1997·Brain : a Journal of Neurology·P SoliveriC D Marsden
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·A KarniL G Ungerleider
Apr 18, 1998·Journal of Neurophysiology·J ClassenL G Cohen
Oct 19, 1999·Human Brain Mapping·C J Price, K J Friston
Nov 18, 2000·Journal of Neurology·K NakanoH Ushiro
Apr 9, 2001·Experimental Brain Research·W MuellbacherM Hallett
Aug 29, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·O MawlawiM Laruelle
Jan 25, 2002·Nature·Wolf MuellbacherMark Hallett
Jan 23, 2003·Brain : a Journal of Neurology·Ines K GoerendtUNKNOWN PET study
Mar 7, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Diana MartinezMarc Laruelle
Aug 26, 2003·Brain : a Journal of Neurology·Antonio P StrafellaAlain Dagher
Dec 3, 2003·Neural Plasticity·Henk J Groenewegen
Mar 30, 2004·Annals of Neurology·Stéphane LehéricyDae-Shik Kim
Jun 17, 2005·Brain : a Journal of Neurology·Tao Wu, Mark Hallett
Jun 29, 2005·Annals of Neurology·Agnes FlöelLeonardo G Cohen
Aug 19, 2005·Proceedings of the National Academy of Sciences of the United States of America·Stéphane LehéricyJulien Doyon
Nov 18, 2005·Trends in Neurosciences·John W Krakauer, Reza Shadmehr
Mar 22, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Anna BrückJuha O Rinne
May 4, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Ann L Smiley-OyenQuinn R Emerson
Dec 22, 2006·Journal of Neurophysiology·Yoshiya MatsuzakaPeter L Strick
Sep 15, 2007·Brain : a Journal of Neurology·D MuslimovicB Schmand
Sep 25, 2007·NeuroImage·Rajendra D BadgaiyanNathaniel M Alpert
Nov 14, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Ji Youn KimByeong Joon Kim

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Jan 10, 2020·Journal of Neuroscience Research·Talia N Lerner
Feb 4, 2022·Sports Medicine·Filipe Oliveira de AlmeidaCarla Silva-Batista

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