PMID: 9423934Jan 10, 1998Paper

Reduced striatal tyrosine hydroxylase activity is not accompanied by change in responsiveness of dopaminergic receptors following chronic treatment with deprenyl

Neuropharmacology
I Lamensdorf, J P Finberg

Abstract

Deprenyl is the only selective monoamine oxidase B (MAO-B) inhibitor that is in clinical use for the treatment of Parkinson's disease. Our previous studies showed that chronic treatment of rats with low (MAO-B selective) doses of deprenyl inhibited dopamine (DA) re-uptake and enhanced DA release in the striatum. These changes could affect DA synthesis rate by activation of negative feedback loops. Chronic deprenyl treatment has also been suggested to cause down-regulation of release-modulating DA receptors. The effects of chronic and acute treatment with deprenyl on ex vivo striatal tyrosine hydroxylase activity were therefore studied, by determination of steady-state tissue level of DOPA following administration of NSD-1015 (100 mg/kg i.p.). In addition, we assessed changes in the in vivo sensitivity of dopaminergic receptors from the reduction in DOPA extracellular level after systemic apomorphine administration (2.5 mg/kg s.c.), following elevation of microdialysate DOPA by systemic or local aromatic amino acid decarboxylase inhibition with NSD-1015. Chronic treatment with deprenyl (0.25 mg/kg s.c. daily for 21 days) caused a significant reduction in tyrosine hydroxylase activity to 60% of control, with no change in the apom...Continue Reading

References

Sep 1, 1992·Journal of Neurochemistry·X M LiA A Boulton
Sep 1, 1990·Journal of Neuroscience Methods·G W ArbuthnottS P Butcher
Jun 1, 1993·Cellular and Molecular Neurobiology·P R Paetsch, A J Greenshaw

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Citations

Jul 2, 2008·Parkinsonism & Related Disorders·P FoleyP Riederer
Sep 8, 2005·Brain Research Bulletin·Yushi U AdachiTomiei Kazama
Sep 22, 2012·Neurochemistry International·Mohammed Abul KashemIain S McGregor
Dec 15, 2005·The Journal of Pharmacology and Experimental Therapeutics·Sevil YasarGianluigi Tanda
May 12, 2006·Critical Reviews in Toxicology·E Mariussen, F Fonnum

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