Abstract
Background and objectives: Patients with atrial fibrillation (AF) reportedly have a much higher risk of death due to stroke. Faced with this heavy burden, it remains unclear if the Chinese herbal medicines (CHMs), the most common form complementary and alternative medicine, can lower the risk of stroke for them. This study aimed to evaluate the association of CHMs use with stroke risk among them. From a nationwide database, 11,456 AF patients aged ≧ 20 years between 1998 and 2007 were identified. Afterwards, we enrolled 2670 CHMs users and randomly selected 2670 non-CHMs users using the propensity score method. The occurrence of stroke was recorded until the end of 2012. Within the follow-up period, 671 CHMs users and 900 non-CHMs users developed stroke, with incidence rates of 33.02 and 45.46 per 1000 person-years, respectively. CHMs use was associated with a 30% lower stroke risk, especially for those receiving CHMs for over two years. The findings of the present study suggest that adding CHMs to conventional therapy could decrease subsequent stroke risk for AF patients. It is also suggested that prospective randomized trials are needed to further clarify if the detected association revealed in this study supports a causal li...Continue Reading
References
May 10, 2001·JAMA : the Journal of the American Medical Association·A S GoD E Singer
Sep 29, 2004·European Heart Journal·Christina StegerClaudia Stöllberger
Jan 18, 2006·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Jian-Ping Liu
Oct 13, 2006·Complementary Therapies in Clinical Practice·Jun Tze SawYu Hoe Lim
Jul 10, 2010·Methods in Molecular Biology·Shaker A Mousa
Jul 17, 2010·Journal of Ethnopharmacology·Haihua ShuKazuo Hanaoka
Sep 30, 2010·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·A John CammUNKNOWN ESC Committee for Practice Guidelines
Nov 16, 2010·Evidence-based Complementary and Alternative Medicine : ECAM·Chih-Jen WuJoen-Rong Sheu
Mar 11, 2011·Chinese Journal of Integrative Medicine·Wei WangXiao-Juan Tao
Mar 29, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Yue LiuKe-Ji Chen
Jun 19, 2012·Journal of Ethnopharmacology·Jiun-Yu ChenChuan-Mu Chen
Sep 26, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Guo-Zhong YiLi-Xia Yuan
Dec 17, 2014·PharmacoEconomics·Andrej Janzic, Mitja Kos
Oct 20, 2015·The American Journal of Chinese Medicine·I-Ling HungTsai-Chung Li
Apr 20, 2016·Journal of Ethnopharmacology·Chia-Chi ChangHung-Rong Yen
Jun 14, 2016·Journal of Thoracic Disease·Sai-Bo PanYing Chai
Jul 11, 2016·Lancet·Jeffrey D StanawayGraham S Cooke
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Paula Mendonça LeiteRachel Oliveira Castilho
Dec 3, 2016·Curēus·Shilpa D Kailas, Sirisha Reddy Thambuluru
Jan 18, 2017·Journal of Pharmacopuncture·Mehrab DashtdarMohammad Khabaz Shirazi
Jan 27, 2017·BMJ Open·Tzung-Yi TsaiChia-Chou Yeh
Feb 10, 2017·PloS One·Qianru ZhangYuanjia Hu
Mar 1, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Yan DongJie Wang
Apr 6, 2017·The Cochrane Database of Systematic Reviews·Danielle E ClarkesmithDeirdre A Lane
Jun 18, 2017·Complementary Therapies in Medicine·Zhangsheng WangJunbo Ge
Sep 11, 2017·American Heart Journal·Elizabeth S O'NeillMegan Coylewright